ABO incompatibility does not influence transfusion requirements in patients undergoing single-unit umbilical cord blood transplantation

• Published in: Bone marrow transplantation (Basingstoke) Vol. 52; no. 3; pp. 394 - 399
• Main Authors: Solves, P, Carpio, N, Carretero, C, Lorenzo, J I, Sanz, J, Gómez, I, López-Chuliá, F, Arilla, M J, Regadera, A I, Montesinos, P, Sanz, G F, Sanz, M Á
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.03.2017
• Subjects: ABO Blood-Group System; ABO system; Adolescent; Adult; Aged; Allografts; Anemia; Antibodies; Autoimmune hemolytic anemia; Blood; Blood Group Incompatibility; Blood Grouping and Crossmatching; Blood transfusion; Bone marrow; Cord blood; Cord Blood Stem Cell Transplantation; Female; Hematologic Neoplasms - therapy; Hematopoietic stem cells; Humans; Impact analysis; Incompatibility; Male; Matching; Methods; Middle Aged; Patients; Physiological aspects; Stem cell transplantation; Stem cells; Transfusion; Transplantation; Umbilical cord
• ISSN: 0268-3369; 1476-5365
• DOI: 10.1038/bmt.2016.264

Hematopoietic stem cell transplantation is usually performed without considering the ABO compatibility between donor and recipient. There are few studies analyzing ABO matching impact on transfusion outcome of umbilical cord blood transplantation (UCBT) recipients. The aim of this study was to analyze factors influencing transfusion outcome, highlighting the ABO matching between donor and recipient. This study has reviewed data from 318 patients who underwent single unit UCBT at la Fe University Hospital from January 2000 to December 2014. There were no differences between RBC and platelet (PLT) requirements or RBC and PLT transfusion independence according to ABO matching between donor and recipient. RBC and PLT requirements were statistically correlated (ρ=0,841, P<0.001). A total of 170 and 188 patients achieved RBC and PLT independence, respectively, within 180 days after UCBT. Persistence of recipient isoagglutinins was detected in 6.8% of patients with major ABO incompatibility at median of 176 days (103-269) after UCBT. Autoimmune haemolytic anemia was diagnosed in 15 patients, 12 of them due to cold antibodies. In conclusion, ABO matching has not influenced transfusion requirements of patients undergoing UCBT.