Pregnancy Outcome in Female Liver Transplant Recipients

• Published in: Transplantation proceedings Vol. 43; no. 4; pp. 1337 - 1339
• Main Authors: Costa, M.L.B, Surita, F.G.C, Passini, R, Cecatti, J.G, Boin, I.F.S.F
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier Inc 01.05.2011; Elsevier
• Subjects: Adult; Biological and medical sciences; Female; Fertility; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; Immunosuppressive Agents - therapeutic use; Liver Transplantation - adverse effects; Medical sciences; Pregnancy; Pregnancy Complications - etiology; Pregnancy Outcome; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Time Factors; Tissue, organ and graft immunology; Young Adult; Human; Prognosis; Digestive system; Liver; Transplantation; Homotransplantation; Pregnancy; Medicine; Treatment; Surgery; Evolution; Female; Graft; Woman
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2011.02.026

Abstract Transplantation has become an available and successful treatment option for numerous congenital and acquired hepatic disorders. Studies have shown that when the prepregnancy recipient graft function is stable and adequate, pregnancy is normally well tolerated with favorable neonatal outcomes. However, there are reports of increased incidences of hypertension and preeclampsia as well as lower birth weights and prematurity. Patients administered tacrolimus-based therapies seem to have lower incidences of these complications. Case Reports The 5 reported patients, aged 23–37 years at the time of conception, were 2–11 years posttransplantation. A preterm delivery for fetal distress was the most clinically important complication among these patients. One episode of acute genital herpes infection, 1 liver hematoma in a patient who was anticoagulated owing to a history of deep vein thrombosis, and 1 case of wound infection postpartum were also observed. Despite these complications, all 5 pregnancies were successful. The mean gestational age at delivery was 35.2 weeks. No structural malformations or early complications were observed in the neonates. All cases showed stable liver parameters.