Beneficial and Adverse Effects of Electro-acupuncture Assessed in the Canine Chronic Atrio-ventricular Block Model Having Severe Hypertension and Chronic Heart Failure

• Published in: Acupuncture & electro-therapeutics research Vol. 40; no. 2; pp. 87 - 99
• Main Authors: Cao, Xin, Lu, Shengfeng, Ohara, Hiroshi, Nakamura, Yuji, Izumi-Nakaseko, Hiroko, Ando, Kentaro, Zhu, Bingmei, Xu, Bin, Sugiyama, Atsushi
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA Cognizant Communication Corporation 01.01.2015; SAGE Publications
• Subjects: Acupuncture; Acupuncture Points; Animals; Atrio-Ventricular Block; Atrioventricular Block - complications; Atrioventricular Block - physiopathology; Atrioventricular Block - therapy; Blood Pressure; Cardiac Output; Chronic Disease - therapy; Disease Models, Animal; Dogs; Electro-Acupuncture; Electroacupuncture; Electroacupuncture - adverse effects; Electrocardiogram; Female; Heart failure; Heart Failure - complications; Heart Failure - physiopathology; Heart Failure - therapy; Heart Rate; Humans; Hypertension; Hypertension - complications; Hypertension - physiopathology; Hypertension - therapy; Male; Safety Assessment; Severe Hypertension; Vascular Resistance; Blood Pressure; Heart Rate; Atrio-Ventricular Block; Severe Hypertension; Safety Assessment; Electrocardiogram; Electro-Acupuncture
• ISSN: 0360-1293; 2167-9010
• DOI: 10.3727/036012915X14381285982886

Regarding the effects of electro-acupuncture for severe hypertension, we assessed its acute cardiovascular consequences with 4 subjects of the chronic atrioventricular block dogs having severe hypertension and chronic heart failure. The electro-acupuncture consisting of 2 mA at 2 Hz frequency was carried out for 30 min at Renying (ST-9) and Taichong (LR-3) every other day. Seven sessions were performed within 2 weeks. In the 1st and 7th sessions, the animals were anesthetized with pentobarbital to analyze the effects of the electro-acupuncture on cardiovascular variables. No significant change was detected in any of the basal control values of the cardiohemodynamic or electrophysiological variables between the 1st and 7th sessions. During the 1st session, electo-acupuncture produced a peak increase in mean blood pressure by 8.7% at 35 min (p<0.05), whereas during the 7th session the peak increase was 6.5% at 35 min (p=0.06). There was no significant change in the cardiac output, total peripheral resistance, a product of the heart rate and systolic blood pressure (=double product) reflecting myocardial oxygen consumption, QRS width or QT interval during the electrical stimulation in the 1st or 7th session. The results suggest that electroacupuncture may not exert lethal adverse effect except the vasopressor response, but that it can decrease the treatment-induced sympathetic response including vasopressor reaction and tachycardia. Since electro-acupuncture may have some potential to induce hypertensive crisis at the beginning, clinicians have to pay attention on its use for patients with hypertension.