Partial protective effect of inactivated Japanese encephalitis vaccine on lethal West Nile virus infection in mice

• Published in: Vaccine Vol. 21; no. 31; pp. 4514 - 4518
• Main Authors: Takasaki, Tomohiko, Yabe, Sadao, Nerome, Reiko, Ito, Mikako, Yamada, Ken-Ichiro, Kurane, Ichiro
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 07.11.2003; Elsevier; Elsevier Limited
• Subjects: Animals; Animals, Suckling; Arboviral encephalitis; Arboviroses; Biological and medical sciences; Brain; Brain research; Cross Reactions; Encephalitis; Experiments; Flaviviridae; Fundamental and applied biological sciences. Psychology; Human viral diseases; Immunization; Infections; Infectious diseases; Injections; Injections, Intraperitoneal; Japanese Encephalitis Vaccines - therapeutic use; Japanese encephalitis virus; Medical sciences; Mice; Microbiology; Neutralization Tests; Tropical viral diseases; Vaccine; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies; Vaccines, Inactivated; Vector-borne diseases; Viral diseases; Virology; West Nile Fever - prevention & control; West Nile virus; West Nile virus - pathogenicity; Japan; Japanese encephalitis virus; Vaccine; Flaviviridae; West Nile virus; Immunoprotection; Rodentia; Flavivirus; Cerebral disorder; Infection; Virus; Vertebrata; Mammalia; West Nile encephalitis; Mouse; Viral disease; Arbovirus disease; Central nervous system disease; Japanese encephalitis group virus; Japanese encephalitis
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/S0264-410X(03)00507-3

The effect of mouse brain-derived, inactivated Japanese encephalitis (JE) vaccine on West Nile virus (WNV) infection was examined using a murine model. Mice were immunized with JE vaccine twice and challenged with lethal doses of WNV. When mice were intracranially challenged with WNV, none of the immunized mice were protected. When mice were intraperitoneally challenged, the immunized mice were protected at higher immunization levels. Cross-reactive neutralizing antibodies to WNV were induced by immunization with JE vaccine; however, the levels were much lower than those to JEV. These results indicate that the currently available mouse brain-derived inactivated JE vaccine can induce partial protective immunity to WNV in mice.