A 5-Year Longitudinal Study of Fatigue in Patients With Late-Onset Sequelae of Poliomyelitis

• Published in: Archives of physical medicine and rehabilitation Vol. 92; no. 6; pp. 899 - 904
• Main Authors: Tersteeg, Irene M., MD, Koopman, Fieke S., MD, Stolwijk-Swüste, Janneke M., MD, PhD, Beelen, Anita, PhD, Nollet, Frans, MD, PhD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.06.2011; Elsevier
• Subjects: Adaptation, Psychological; Age of Onset; Aged; Biological and medical sciences; Diseases of the osteoarticular system; Fatigue; Fatigue - epidemiology; Fatigue - psychology; Female; Health Status Indicators; Human viral diseases; Humans; Infectious diseases; Longitudinal Studies; Male; Medical sciences; Middle Aged; Miscellaneous; Physical Medicine and Rehabilitation; Poliovirus; Postpoliomyelitis syndrome; Postpoliomyelitis Syndrome - epidemiology; Postpoliomyelitis Syndrome - psychology; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Rehabilitation; Time Factors; Viral diseases; Viral diseases of the nervous system; LOSP; Comorbidity and Aging effects in Rehabilitation Patients on Activities; GEE; generalized estimating equations; late-onset sequelae of poliomyelitis; FSS; Fatigue; CARPA; Medical Outcomes Study 36-Item Short-Form Health Survey; SF-36; postpolio syndrome; Postpoliomyelitis syndrome; PPS; CIRS; Longitudinal studies; Rehabilitation; Cumulative Illness Rating Scale; Fatigue Severity Scale; Human; Nervous system diseases; Acute anterior poliomyelitis; Infection; Reeducation; Viral disease; Orthopedics; Central nervous system disease; Spinal cord disease
• ISSN: 0003-9993; 1532-821X
• DOI: 10.1016/j.apmr.2011.01.005

Abstract Tersteeg IM, Koopman FS, Stolwijk-Swüste JM, Beelen A, Nollet F, on behalf of the CARPA Study Group. A 5-year longitudinal study of fatigue in patients with late-onset sequelae of poliomyelitis. Objectives To study the severity and 5-year course of fatigue in patients with late-onset sequelae of poliomyelitis (LOSP) and to identify physical and psychosocial determinants of fatigue. Design Prospective cohort study with 5 measurements over 5 years. Setting University hospital. Participants Patients with LOSP (N=168); 89% of the subjects completed the study. Interventions Not applicable. Main Outcome Measures Fatigue assessed with the Fatigue Severity Scale (FSS). Potential determinants were perceived physical functioning, bodily pain and mental health, extent of paresis, walking capacity, comorbidity, sleeping disorders, coping, and social support. Associations were investigated by multivariable longitudinal analysis using generalized estimating equations. Results The mean FSS score ± SD at baseline was 5.1±1.4, which did not change significantly during the 5-year follow-up. Reduced physical functioning, increased bodily pain, reduced sleep quality, more psychologic distress, and higher task-oriented coping were independently associated with fatigue. The extent of paresis and walking capacity were strongly associated with physical functioning. Conclusions Fatigue is severe and persistent in patients with LOSP due to physical and psychologic factors, which has implications for counseling and treatment. In addition to the commonly applied interventions targeting physical aspects, psychologic interventions are a potential area for reducing fatigue.