Serious stomatitis and esophagitis: a peculiar mucous reaction induced by pegylated liposomal doxorubicin

• Published in: Anais brasileiros de dermatología Vol. 90; no. 3 Suppl 1; pp. 209 - 211
• Main Authors: Ma, Han, Chen, Meilan, Liu, Junru, Li, Ying, Li, Juan
• Format: Journal Article
• Language: English; Portuguese
• Published: Brazil Sociedade Brasileira de Dermatologia 01.06.2015
• Subjects: Aged; Antibiotics, Antineoplastic - adverse effects; Case Report; DERMATOLOGY; Doxorubicin; Doxorubicin - adverse effects; Doxorubicin - analogs & derivatives; Esophagitis; Esophagitis - chemically induced; Esophagitis - pathology; Female; Gastric Mucosa - drug effects; Hand-Foot Syndrome - etiology; Hand-Foot Syndrome - pathology; Humans; Mouth Mucosa - drug effects; Multiple Myeloma - complications; Multiple Myeloma - drug therapy; Polyethylene Glycols - adverse effects; Stomatitis; Stomatitis - chemically induced; Stomatitis - pathology; Esophagitis; Doxorubicin; Stomatitis
• ISSN: 0365-0596; 1806-4841; 1806-4841; 0365-0596
• DOI: 10.1590/abd1806-4841.20153708

Pegylated liposomal doxorubicin is an important antineoplastic agent with activity in a variety of solid tumors. It has a totally different profile of pharmacokinetics and toxicity compared with doxorubicin. It rarely causes side-effects like cardiotoxicity or hair loss, but frequently results in many kinds of mucocutaneous reactions, including palmar-plantar erythrodysesthesia, diffuse follicular rash, intertrigo-like eruption, new formation of melanotic macules, stomatitis and radiation recall dermatitis. We present a rare case of multiple myeloma who immediately developed serious stomatitis and esophatitis associated with minor palmar-plantar erythrodysesthesia after a single course of pegylated liposomal doxorubicin.