How Institut Georges Lopez Preservation Solution Protects Nonsteatotic and Steatotic Livers Against Ischemia-Reperfusion Injury

• Published in: Transplantation proceedings Vol. 43; no. 1; pp. 77 - 79
• Main Authors: Zaouali, M.A, Ben Abdennebi, H, Padrissa-Altés, S, Alfany-Fernandez, I, Rimola, A, Roselló-Catafau, J
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier Inc 2011; Elsevier
• Subjects: Biological and medical sciences; Fatty Liver - complications; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Medical sciences; Organ Preservation Solutions; Other diseases. Semiology; Reperfusion Injury - etiology; Reperfusion Injury - prevention & control; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Tissue, organ and graft immunology; Preservation; Cardiovascular disease; Hepatic disease; Transplantation; Vascular disease; Medicine; Organ preservation; Treatment; Surgery; Hepatic ischemia reperfusion injury; Digestive diseases; Graft; Protection; Solution
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2010.12.026

Abstract The Institut Georges Lopez preservation solution (IGL-1) is a serum-free organ preservative that has been shown to protect steatotic livers against hepatic ischemia-reperfusion injury. Although several hypotheses have been proposed to explain the graft protection mechanisms induced by IGL-1 solution, they have not been fully investigated. This review assessed possible IGL-1 mechanisms responsible for the increased liver tolerance of ischemia-reperfusion injury with special emphasis on vasodilatator mediators such as nitric oxide, on oxidative stress prevention, on protection against mitochondrial damage, and finally on induction of cytoprotective factors.