The role of miRNA in inflammation and autoimmunity

• Published in: Autoimmunity reviews Vol. 12; no. 12; pp. 1160 - 1165
• Main Authors: Singh, Ram Pyare, Massachi, Israel, Manickavel, Sudhir, Singh, Satendra, Rao, Nagesh P, Hasan, Sascha, Mc Curdy, Deborah K, Sharma, Sherven, Wong, David, Hahn, Bevra H, Rehimi, Hamida
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2013
• Subjects: Allergy and Immunology; Animals; Autoimmune Diseases - genetics; Autoimmune Diseases - immunology; Autoimmune Diseases - therapy; Autoimmunity; Cancer; Gene Expression Regulation; Humans; Inflammation - genetics; Inflammation - immunology; MicroRNA; MicroRNAs - genetics; MicroRNAs - metabolism; Rheumatoid arthritis and Sjögren syndrome; Sex hormones; Systemic lupus erythematosus; Autoimmunity; Sex hormones; Rheumatoid arthritis and Sjögren syndrome; MicroRNA; Systemic lupus erythematosus; Cancer
• ISSN: 1568-9972; 1568-9972; 1873-0183
• DOI: 10.1016/j.autrev.2013.07.003

Abstract miRNAs are small non-coding RNA molecules that modulate the expression of multiple protein-encoding genes at the post-transcriptional level. They have recently been recognized as powerful regulators of numerous genes and pathways in the pathogenesis of inflammatory and autoimmune diseases. The targets of most miRNAs remain unknown and their roles in biological processes such as cell differentiation, proliferation, and death (apoptosis) are not clearly understood. In this review we will discuss how certain candidate miRNAs affect inflammatory and immune mediated diseases by regulating their cellular and molecular targets. We focused the influence of gender and sex hormones on miRNA. We believe that understanding the role of miRNAs could shed light on the cause and progression of many inflammatory and autoimmune diseases and eventually lay the groundwork for therapeutic options.