Susceptibility of mantle cell lymphomas to reovirus oncolysis
Abstract Mantle cell lymphoma (MCL) an incurable B-cell, non-Hodgkin lymphoma (NHL) urgently requires new treatments. We assessed reovirus mediated oncolysis in a panel of human MCL cell lines. In vitro , we found the cytopathic effect of reovirus infection ranged from high to very limited and corre...
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Published in | Leukemia research Vol. 34; no. 1; pp. 100 - 108 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.01.2010
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Subjects | |
Online Access | Get full text |
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Summary: | Abstract Mantle cell lymphoma (MCL) an incurable B-cell, non-Hodgkin lymphoma (NHL) urgently requires new treatments. We assessed reovirus mediated oncolysis in a panel of human MCL cell lines. In vitro , we found the cytopathic effect of reovirus infection ranged from high to very limited and correlated with levels of Ras activation. In vivo , a single reovirus injection intra-tumorally resulted in complete regression of both the injected and the contra-lateral tumor in a subcutaneous bi-tumor model, in one out of three cell lines tested. Reovirus treatment of MCL seems feasible but will need to be guided by the presence of molecular determinants of reovirus susceptibility. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0145-2126 1873-5835 |
DOI: | 10.1016/j.leukres.2009.05.020 |