CADMIUM-INDUCED RENAL LIPID PEROXIDATION IN RATS AND PROTECTION BY SELENIUM
Cadmium has been recognized as one of the most toxic environmental and industrial pollutants. The kidney is a critical target organ following Cd exposure. The aim of this study was to investigate the effects of cadmium-induced peroxidative damage to rat kidney. Treatment of rats with Cd resulted in...
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| Published in | Journal of Toxicology and Environmental Health, Part A Vol. 57; no. 6; pp. 403 - 413 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Informa UK Ltd
23.07.1999
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Cadmium has been recognized as one of the most toxic environmental and industrial pollutants. The kidney is a critical target organ following Cd exposure. The aim of this study was to investigate the effects of cadmium-induced peroxidative damage to rat kidney. Treatment of rats with Cd resulted in a time- and dose-related accumulation of metal in kidney. Cd produced enhanced lipid peroxidation in plasma and kidney. These Cd-induced changes were accompanied by a significant rise in renal Fe and Cu, and a fall in tissue Zn and Se. Concurrent treatment with Se and Cd reduced the Cd-induced alterations in renal peroxidation and essential metal levels. Data suggest that lipid peroxidation is associated with Cd toxicity and that Se was found effective in attenuation of these renal effects. |
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| AbstractList | Cadmium has been recognized as one of the most toxic environmental and industrial pollutants. The kidney is a critical target organ following Cd exposure. The aim of this study was to investigate the effects of cadmium-induced peroxidative damage to rat kidney. Treatment of rats with Cd resulted in a time- and dose-related accumulation of metal in kidney. Cd produced enhanced lipid peroxidation in plasma and kidney. These Cd-induced changes were accompanied by a significant rise in renal Fe and Cu, and a fall in tissue Zn and Se. Concurrent treatment with Se and Cd reduced the Cd-induced alterations in renal peroxidation and essential metal levels. Data suggest that lipid peroxidation is associated with Cd toxicity and that Se was found effective in attenuation of these renal effects. |
| Author | Shuenn-Jiun Yiin, Chi-Liang Chern, Jenn-Yuan Sheu, Wei-Chang Tseng, Te-Hsien Lin |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/10478822$$D View this record in MEDLINE/PubMed |
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| Snippet | Cadmium has been recognized as one of the most toxic environmental and industrial pollutants. The kidney is a critical target organ following Cd exposure. The... |
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| SubjectTerms | Animals Cadmium - pharmacokinetics Cadmium - toxicity Dose-Response Relationship, Drug Environmental Pollutants - pharmacokinetics Environmental Pollutants - toxicity Kidney - drug effects Kidney - metabolism Lipid Peroxidation - drug effects Male Plasma - drug effects Plasma - metabolism Rats Rats, Sprague-Dawley Selenium - pharmacology |
| Title | CADMIUM-INDUCED RENAL LIPID PEROXIDATION IN RATS AND PROTECTION BY SELENIUM |
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