CADMIUM-INDUCED RENAL LIPID PEROXIDATION IN RATS AND PROTECTION BY SELENIUM

Cadmium has been recognized as one of the most toxic environmental and industrial pollutants. The kidney is a critical target organ following Cd exposure. The aim of this study was to investigate the effects of cadmium-induced peroxidative damage to rat kidney. Treatment of rats with Cd resulted in...

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Bibliographic Details
Published inJournal of Toxicology and Environmental Health, Part A Vol. 57; no. 6; pp. 403 - 413
Main Authors Yiin, S J, Chern, C L, Sheu, J Y, Tseng, W C, Lin, T H
Format Journal Article
LanguageEnglish
Published England Informa UK Ltd 23.07.1999
Subjects
Animals
Cadmium - pharmacokinetics
Cadmium - toxicity
Dose-Response Relationship, Drug
Environmental Pollutants - pharmacokinetics
Environmental Pollutants - toxicity
Kidney - drug effects
Kidney - metabolism
Lipid Peroxidation - drug effects
Male
Plasma - drug effects
Plasma - metabolism
Rats
Rats, Sprague-Dawley
Selenium - pharmacology
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Summary:Cadmium has been recognized as one of the most toxic environmental and industrial pollutants. The kidney is a critical target organ following Cd exposure. The aim of this study was to investigate the effects of cadmium-induced peroxidative damage to rat kidney. Treatment of rats with Cd resulted in a time- and dose-related accumulation of metal in kidney. Cd produced enhanced lipid peroxidation in plasma and kidney. These Cd-induced changes were accompanied by a significant rise in renal Fe and Cu, and a fall in tissue Zn and Se. Concurrent treatment with Se and Cd reduced the Cd-induced alterations in renal peroxidation and essential metal levels. Data suggest that lipid peroxidation is associated with Cd toxicity and that Se was found effective in attenuation of these renal effects.
ISSN:1528-7394
1087-2620
DOI:10.1080/009841099157601