Wound healing - A literature review

• Published in: Anais brasileiros de dermatología Vol. 91; no. 5; pp. 614 - 620
• Main Authors: Gonzalez, Ana Cristina de Oliveira, Costa, Tila Fortuna, Andrade, Zilton de Araújo, Medrado, Alena Ribeiro Alves Peixoto
• Format: Journal Article
• Language: English
• Published: Brazil Sociedade Brasileira de Dermatologia 01.09.2016
• Subjects: Cell proliferation; Cell Proliferation - physiology; Collagen - metabolism; DERMATOLOGY; Epithelial-Mesenchymal Transition; Hedgehog proteins; Hedgehog Proteins - physiology; Humans; Inflammation; Neovascularization, Physiologic; Re-Epithelialization - physiology; Review; Wound Healing; Wound Healing - physiology; Cell proliferation; Inflammation; Wound Healing; Hedgehog proteins
• ISSN: 0365-0596; 1806-4841; 1806-4841; 0365-0596
• DOI: 10.1590/abd1806-4841.20164741

Regeneration and tissue repair processes consist of a sequence of molecular and cellular events which occur after the onset of a tissue lesion in order to restore the damaged tissue. The exsudative, proliferative, and extracellular matrix remodeling phases are sequential events that occur through the integration of dynamic processes involving soluble mediators, blood cells, and parenchymal cells. Exsudative phenomena that take place after injury contribute to the development of tissue edema. The proliferative stage seeks to reduce the area of tissue injury by contracting myofibroblasts and fibroplasia. At this stage, angiogenesis and reepithelialization processes can still be observed. Endothelial cells are able to differentiate into mesenchymal components, and this difference appears to be finely orchestrated by a set of signaling proteins that have been studied in the literature. This pathway is known as Hedgehog. The purpose of this review is to describe the various cellular and molecular aspects involved in the skin healing process.