Functional studies of a novel oncogene TGM3 in human esophageal squamous cell carcinoma

• Published in: World journal of gastroenterology : WJG Vol. 12; no. 24; pp. 3929 - 3932
• Main Authors: Liu, Wei, Yu, Zai-Cheng, Cao, Wen-Feng, Ding, Fang, Liu, Zhi-Hua
• Format: Journal Article
• Language: English
• Published: United States Department of Thoracic Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China%National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100021, China 28.06.2006; Baishideng Publishing Group Co., Limited
• Subjects: Adult; Aged; Biomarkers, Tumor - analysis; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - physiopathology; Disease Progression; Esophageal Neoplasms - chemistry; Esophageal Neoplasms - genetics; Esophageal Neoplasms - pathology; Esophageal Neoplasms - physiopathology; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Male; Middle Aged; Neoplasm Staging; Oncogenes - genetics; Oncogenes - physiology; Rapid Communication; Transglutaminases - metabolism; 功能障碍; 病理机制; 致癌基因; 食管鳞状细胞癌; Esophageal squamous cell carcinoma; Tissue microarray; Immunohistochemically
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v12.i24.3929

AIM： To investigate the role of transglutaminase 3 （TGM3） gene in human esophageal squamous cell carcinoma （ESCC）, and analyze its relationship with clinicopathological parameters. METHODS： Gene expression of TGM3 in fresh esophageal cancer tissues and their corresponding normal mucosas was detected immunohistochemically（I HC） by means of tissue microarray（TMA）. Its correlation with clinical characteristics was evaluated and analyzed by univariate analysis. All statistical analyses were performed by SPSS version 10.0. RESULTS： Expression rate of TGM3 was reduced to 81.8% in ESCC. Expression of TGM3 was significantly inversely correlated with histological grade of esophageal carcinoma （in grade I, II and III tumors, the reduced expression was 4/7, 57/71, and 20/21, respectively, P 〈 0.05）, whereas it had no obvious correlations with lymph node metastasis and depth of invasion. CONCLUSION： Reduced expression of TGM3 may play an important role in esophageal carcinogenesis.