Identification of the target self-antigens in reperfusion injury

Reperfusion injury (RI), a potential life-threatening disorder, represents an acute inflammatory response after periods of ischemia resulting from myocardial infarction, stroke, surgery, or trauma. The recent identification of a monoclonal natural IgM that initiates RI led to the identification of n...

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Published inThe Journal of experimental medicine Vol. 203; no. 1; pp. 141 - 152
Main Authors Zhang, Ming, Alicot, Elisabeth M, Chiu, Isaac, Li, Jinan, Verna, Nicola, Vorup-Jensen, Thomas, Kessler, Benedikt, Shimaoka, Motomu, Chan, Rodney, Friend, Daniel, Mahmood, Umar, Weissleder, Ralph, Moore, Francis D, Carroll, Michael C
Format Journal Article
LanguageEnglish
Published United States The Rockefeller University Press 23.01.2006
Subjects
Animals
Autoantigens - immunology
Autoimmunity
Capillary Permeability
Hindlimb
Homeodomain Proteins - genetics
Immunity, Innate
Immunoglobulin M - immunology
Ischemia
Jejunum - immunology
Jejunum - pathology
Mice
Mice, Inbred C57BL
Mice, Knockout
Muscle, Skeletal - immunology
Muscle, Skeletal - pathology
Nonmuscle Myosin Type IIA - immunology
Reperfusion Injury - immunology
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Summary:Reperfusion injury (RI), a potential life-threatening disorder, represents an acute inflammatory response after periods of ischemia resulting from myocardial infarction, stroke, surgery, or trauma. The recent identification of a monoclonal natural IgM that initiates RI led to the identification of nonmuscle myosin heavy chain type II A and C as the self-targets in two different tissues. These results identify a novel pathway in which the innate response to a highly conserved self-antigen expressed as a result of hypoxic stress results in tissue destruction.
Bibliography:ObjectType-Article-1
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CORRESPONDENCE Michael C. Carroll: carroll@cbr.med.harvard.edu
Abbreviations used: ANOVA, analysis of variance; Hc, heavy chain; HRP, horseradish peroxidase; MBL, mannan-binding lectin; NMHC-II, nonmuscle myosin Hc type II; PARS, poly(ADP ribose) synthetase; PL, phospholipd; RI, reperfusion injury; ROS, reactive oxygen species; SPR, surface plasmon resonance.
ISSN:0022-1007
1540-9538
1540-9538
1892-1007
DOI:10.1084/jem.20050390