Etanercept in erythema nodosum leprosum
One of the biggest challenges in treating leprosy is the control of reaction events. Patients with lepromatous leprosy may present reaction type II, or erythema nodosum leprosum, during treatment, and this reaction can remain in a recurrent form after being released from the hospital, requiring the...
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Published in | Anais brasileiros de dermatología Vol. 92; no. 4; pp. 575 - 577 |
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Main Authors | , , , |
Format | Journal Article |
Language | English Portuguese |
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Sociedade Brasileira de Dermatologia
01.07.2017
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Abstract | One of the biggest challenges in treating leprosy is the control of reaction events. Patients with lepromatous leprosy may present reaction type II, or erythema nodosum leprosum, during treatment, and this reaction can remain in a recurrent form after being released from the hospital, requiring the use of thalidomide and/or prednisone for long periods of time, in turn increasing the risk of side effects. Two reports of the use of antiTNF to treat erythema nodosum leprosum were found in the literature. A good response was found after an assay with infliximab and etanercept. This study reports on a patient with lepromatous leprosy and recurrent reaction, controlled by using etanercept and a 10-month follow-up, with the interruption of thalidomide and the maintenance of prednisone at 10 mg/day. |
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AbstractList | One of the biggest challenges in treating leprosy is the control of reaction events. Patients with lepromatous leprosy may present reaction type II, or erythema nodosum leprosum, during treatment, and this reaction can remain in a recurrent form after being released from the hospital, requiring the use of thalidomide and/or prednisone for long periods of time, in turn increasing the risk of side effects. Two reports of the use of antiTNF to treat erythema nodosum leprosum were found in the literature. A good response was found after an assay with infliximab and etanercept. This study reports on a patient with lepromatous leprosy and recurrent reaction, controlled by using etanercept and a 10-month follow-up, with the interruption of thalidomide and the maintenance of prednisone at 10 mg/day. One of the biggest challenges in treating leprosy is the control of reaction events. Patients with lepromatous leprosy may present reaction type II, or erythema nodosum leprosum, during treatment, and this reaction can remain in a recurrent form after being released from the hospital, requiring the use of thalidomide and/or prednisone for long periods of time, in turn increasing the risk of side effects. Two reports of the use of antiTNF to treat erythema nodosum leprosum were found in the literature. A good response was found after an assay with infliximab and etanercept. This study reports on a patient with lepromatous leprosy and recurrent reaction, controlled by using etanercept and a 10-month follow-up, with the interruption of thalidomide and the maintenance of prednisone at 10 mg/day. |
Author | Vendramini, Dâmia Leal Avelleira, João Carlos Regazzi Nery, José Augusto da Costa Santos, Julia Rocha Silva |
AuthorAffiliation | 3 Dermatology Service, Hospital Federal da Lagoa - Rio de Janeiro (RJ), Brazil 2 Leprosy Laboratory, Fundação Oswaldo Cruz, Fiocruz - Rio de Janeiro (RJ), Brazil 1 Professor Rubem David Azulay Dermatology Institute, Santa Casa de Misericórdia do Rio de Janeiro (DPRDA-SCMRJ) - Rio de Janeiro (RJ), Brazil |
AuthorAffiliation_xml | – name: 2 Leprosy Laboratory, Fundação Oswaldo Cruz, Fiocruz - Rio de Janeiro (RJ), Brazil – name: 3 Dermatology Service, Hospital Federal da Lagoa - Rio de Janeiro (RJ), Brazil – name: 1 Professor Rubem David Azulay Dermatology Institute, Santa Casa de Misericórdia do Rio de Janeiro (DPRDA-SCMRJ) - Rio de Janeiro (RJ), Brazil – name: Santa Casa de Misericórdia do Rio de Janeiro – name: Fiocruz – name: Hospital Federal da Lagoa |
Author_xml | – sequence: 1 givenname: Julia Rocha Silva surname: Santos fullname: Santos, Julia Rocha Silva organization: Professor Rubem David Azulay Dermatology Institute, Santa Casa de Misericórdia do Rio de Janeiro (DPRDA-SCMRJ) - Rio de Janeiro (RJ), Brazil – sequence: 2 givenname: Dâmia Leal surname: Vendramini fullname: Vendramini, Dâmia Leal organization: Professor Rubem David Azulay Dermatology Institute, Santa Casa de Misericórdia do Rio de Janeiro (DPRDA-SCMRJ) - Rio de Janeiro (RJ), Brazil – sequence: 3 givenname: José Augusto da Costa surname: Nery fullname: Nery, José Augusto da Costa organization: Leprosy Laboratory, Fundação Oswaldo Cruz, Fiocruz - Rio de Janeiro (RJ), Brazil – sequence: 4 givenname: João Carlos Regazzi surname: Avelleira fullname: Avelleira, João Carlos Regazzi organization: Dermatology Service, Hospital Federal da Lagoa - Rio de Janeiro (RJ), Brazil |
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Cites_doi | 10.1056/NEJMc052955 10.1093/cid/ciq213 10.1136/ard.55.11.833 10.1128/IAI.60.4.1441-1446.1992 10.1136/gut.50.2.196 |
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Keywords | Leprosy Erythema nodosum Tumor necrosis factor-alpha |
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References_xml | – volume: 355 start-page: 739 year: 2006 ident: ref8 article-title: Treatment of recurrent erythema nodosum leprosum with infliximab publication-title: N Engl J Med doi: 10.1056/NEJMc052955 contributor: fullname: Faber WR – year: 2015 ident: ref1 contributor: fullname: Talhari S – volume: 52 start-page: e133 year: 2011 ident: ref9 article-title: Severe refractory erythema nodosum successfully treated with the tumor necrosis factor inhibitor etanercept publication-title: Clin Infect Dis doi: 10.1093/cid/ciq213 contributor: fullname: Ramien ML – volume: 84 start-page: 103 year: 1991 ident: ref2 article-title: Serum levels of tumour necrosis factor-alpha and interleukin-1β during leprosy reactional states publication-title: Clin Exp Immunol contributor: fullname: Sarno EN – volume: 76 start-page: 39 year: 2001 ident: ref5 article-title: Estudo aberto com pentoxifilina em pacientes com psoríase publication-title: An Bras Dermatol contributor: fullname: Rigoni ACM – volume: 66 start-page: 261 year: 1995 ident: ref7 article-title: Pentoxifiline may be useful in the treatment of type 2 leprosy reaction publication-title: Lepr Rev contributor: fullname: Talhari S – volume: 55 start-page: 833 year: 1996 ident: ref4 article-title: An open study of pentoxifylline and thalidomide as adjuvant therapy in the treatment of rheumatoid arthritis publication-title: Ann Rheum Dis doi: 10.1136/ard.55.11.833 contributor: fullname: Huizinga TW – volume: 60 start-page: 1441 year: 1992 ident: ref3 article-title: Tumor necrosis factor production in patients with leprosy publication-title: Infect Immun doi: 10.1128/IAI.60.4.1441-1446.1992 contributor: fullname: Barnes PF – volume: 50 start-page: 196 year: 2002 ident: ref6 article-title: Thalidomide reduces tumour necrosis factor α and interleukin 12 production in patients with chronic active Crohn's disease publication-title: Gut doi: 10.1136/gut.50.2.196 contributor: fullname: Bauditz J – volume: 66 start-page: 261 year: 1995 end-page: 263 article-title: Pentoxifiline may be useful in the treatment of type 2 leprosy reaction publication-title: Lepr Rev contributor: fullname: Talhari, S; Orsi, AT; Talhari, AC; Souza, FH; Ferreira, LC – year: 2015 publication-title: Hanseníase contributor: fullname: Talhari, S; Penna, GO; Gonçalves, HS; Oliveira, MLW – volume: 76 start-page: 39 year: 2001 end-page: 49 article-title: Estudo aberto com pentoxifilina em pacientes com psoríase publication-title: An Bras Dermatol contributor: fullname: Rigoni, ACM; Carneiro, SCS – volume: 55 start-page: 833 year: 1996 end-page: 836 article-title: An open study of pentoxifylline and thalidomide as adjuvant therapy in the treatment of rheumatoid arthritis publication-title: Ann Rheum Dis contributor: fullname: Huizinga, TW; Dijkmans, BA; van der Velde, EA; van de Pouw Kraan, TC; Verweij, CL; Breedveld, FC – volume: 84 start-page: 103 year: 1991 end-page: 108 article-title: Serum levels of tumour necrosis factor-alpha and interleukin-1β during leprosy reactional states publication-title: Clin Exp Immunol contributor: fullname: Sarno, EN; Grau, GE; Vieira, LM; Nery, JA – volume: 60 start-page: 1441 year: 1992 end-page: 1446 article-title: Tumor necrosis factor production in patients with leprosy publication-title: Infect Immun contributor: fullname: Barnes, PF; Chatterjee, D; Brennan, PJ; Rea, TH; Modlin, RL – volume: 355 start-page: 739 year: 2006 end-page: 739 article-title: Treatment of recurrent erythema nodosum leprosum with infliximab publication-title: N Engl J Med contributor: fullname: Faber, WR; Jensema, AJ; Goldschmidt, WF – volume: 52 start-page: e133 year: 2011 end-page: e135 article-title: Severe refractory erythema nodosum successfully treated with the tumor necrosis factor inhibitor etanercept publication-title: Clin Infect Dis contributor: fullname: Ramien, ML; Wong, A; Keystone, JS – volume: 50 start-page: 196 year: 2002 end-page: 200 article-title: Thalidomide reduces tumour necrosis factor α and interleukin 12 production in patients with chronic active Crohn's disease publication-title: Gut contributor: fullname: Bauditz, J; Wedel, S; Lochs, H |
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SubjectTerms | Adult Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Communication DERMATOLOGY Erythema nodosum Erythema Nodosum - drug therapy Etanercept - therapeutic use Humans Immunosuppressive Agents - therapeutic use Leprosy Leprosy, Lepromatous - drug therapy Male Prednisone - therapeutic use Thalidomide - therapeutic use Tumor necrosis factor-alpha |
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Title | Etanercept in erythema nodosum leprosum |
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