Effect of Polyphenols Intake on Obesity-Induced Maternal Programming

Excess caloric intake and body fat accumulation lead to obesity, a complex chronic disease that represents a significant public health problem due to the health-related risk factors. There is growing evidence showing that maternal obesity can program the offspring, which influences neonatal phenotyp...

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Bibliographic Details
Published inNutrients Vol. 13; no. 7; p. 2390
Main Authors Fortunato, Isabela Monique, dos Santos, Tanila Wood, Ferraz, Lucio Fábio Caldas, Santos, Juliana Carvalho, Ribeiro, Marcelo Lima
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.07.2021
MDPI
Subjects
Adipocytes
adipose tissue
Antioxidants
Bioactive compounds
Body fat
Breastfeeding & lactation
Chronic diseases
Diabetes
Disease
DNA methylation
Epigenetics
Fetus
Fetuses
Genetic crosses
Growth
Health aspects
Health risks
Hyperplasia
Inflammation
maternal obesity
Metabolic disorders
Metabolism
Metabolites
Neonates
nutraceutical
Nutrition research
Obesity
Offspring
Overweight
Oxidants
Oxidizing agents
Phenotypes
Physiology
Polyphenols
Pregnancy
Progeny
Proteins
Puberty
Public health
Review
Risk analysis
Risk factors
Stem cells
Transcription factors
Weaning
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Summary:Excess caloric intake and body fat accumulation lead to obesity, a complex chronic disease that represents a significant public health problem due to the health-related risk factors. There is growing evidence showing that maternal obesity can program the offspring, which influences neonatal phenotype and predispose offspring to metabolic disorders such as obesity. This increased risk may also be epigenetically transmitted across generations. Thus, there is an imperative need to find effective reprogramming approaches in order to resume normal fetal development. Polyphenols are bioactive compounds found in vegetables and fruits that exert its anti-obesity effect through its powerful anti-oxidant and anti-inflammatory activities. Polyphenol supplementation has been proven to counteract the prejudicial effects of maternal obesity programming on progeny. Indeed, some polyphenols can cross the placenta and protect the fetal predisposition against obesity. The present review summarizes the effects of dietary polyphenols on obesity-induced maternal reprogramming as an offspring anti-obesity approach.
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ISSN:2072-6643
2072-6643
DOI:10.3390/nu13072390