Zwittermicin A: Synthesis of analogs and structure–activity studies

Analogs and diastereomers of the natural product zwittermicin A were prepared. SAR studies of these compounds reveal the antifungal activity to be dependent singularly upon the natural constitution and configuration.

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 20; no. 7; pp. 2183 - 2185
Main Authors Rogers, Evan W., Dalisay, Doralyn S., Molinski, Tadeusz F.
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier Ltd 01.04.2010
Elsevier
Subjects
Amino alcohol
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antibodies
Antifungal
Antifungal agents
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Bacillus cereus - chemistry
Biological and medical sciences
Fungi - drug effects
Medical sciences
Microbial Sensitivity Tests
Molecular Structure
Peptides - chemistry
Peptides - pharmacology
Pharmacology. Drug treatments
Stereoisomerism
Structure-Activity Relationship
Synthesis
Amino alcohol
Antifungal
Synthesis
Antifungal agent
Aminoalcohol
Structure activity relation
Aliphatic compound
Ureas
Chemical synthesis
In vitro
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Summary:Analogs and diastereomers of the natural product zwittermicin A were prepared. SAR studies of these compounds reveal the antifungal activity to be dependent singularly upon the natural constitution and configuration.
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Present addresses: DSD, Department of Chemistry, University of British Columbia, Vancouver, BC, Canada V6T 1Z1. EWR, CalciMedica, 505 Coast Boulevard South, La Jolla, CA
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2010.02.032