An overview of the clinical applications of optical coherence tomography angiography

• Published in: Eye (London) Vol. 32; no. 2; pp. 262 - 286
• Main Authors: Tan, A C S, Tan, G S, Denniston, A K, Keane, P A, Ang, M, Milea, D, Chakravarthy, U, Cheung, C M G
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2018; Nature Publishing Group
• Subjects: 692/699/3161/1626; 692/699/3161/3163; 692/699/3161/3172; 692/699/3161/3175; 692/699/3161/3177; Age; Angiography; Artefacts; Diagnostic Techniques, Ophthalmological; Dyes; Fluorescein Angiography - methods; Humans; Inflammatory diseases; Laboratory Medicine; Macular degeneration; Medical imaging; Medicine; Medicine & Public Health; Ophthalmology; Optic nerve; Pharmaceutical Sciences/Technology; Retina; Retinal Diseases - diagnostic imaging; Review; Reviews; Surgery; Surgical Oncology; Therapeutic applications; Tomography; Tomography, Optical Coherence - methods; Vascular diseases
• ISSN: 0950-222X; 1476-5454
• DOI: 10.1038/eye.2017.181

Optical coherence tomography angiography (OCTA) has emerged as a novel, non-invasive imaging modality that allows the detailed study of flow within the vascular structures of the eye. Compared to conventional dye angiography, OCTA can produce more detailed, higher resolution images of the vasculature without the added risk of dye injection. In our review, we discuss the advantages and disadvantages of this new technology in comparison to conventional dye angiography. We provide an overview of the current OCTA technology available, compare the various commercial OCTA machines technical specifications and discuss some future software improvements. An approach to the interpretation of OCTA images by correlating images to other multimodal imaging with attention to identifying potential artefacts will be outlined and may be useful to ophthalmologists, particularly those who are currently still unfamiliar with this new technology. This review is based on a search of peer-reviewed published papers relevant to OCTA according to our current knowledge, up to January 2017, available on the PubMed database. Currently, many of the published studies have focused on OCTA imaging of the retina, in particular, the use of OCTA in the diagnosis and management of common retinal diseases such as age-related macular degeneration and retinal vascular diseases. In addition, we describe clinical applications for OCTA imaging in inflammatory diseases, optic nerve diseases and anterior segment diseases. This review is based on both the current literature and the clinical experience of our individual authors, with an emphasis on the clinical applications of this imaging technology.