The association between sedentary behavior, physical activity and hyperuricemia

• Published in: Vascular health and risk management Vol. 15; pp. 291 - 299
• Main Authors: Park, Doo Yong, Kim, Yeon Soo, Ryu, Seung Ho, Jin, Yu Sun
• Format: Journal Article
• Language: English
• Published: New Zealand Dove 01.01.2019; Dove Medical Press
• Subjects: Adolescent; Adult; Aged; Biomarkers - blood; Cardiovascular Diseases; Cross-Sectional Studies; Epidemiology; Exercise; Female; Healthy Lifestyle; Humans; Hyperuricemia - blood; Hyperuricemia - diagnosis; Hyperuricemia - epidemiology; Hyperuricemia - prevention & control; Male; Middle Aged; Original Research; Prevalence; Protective Factors; Republic of Korea - epidemiology; Retrospective Studies; Risk Assessment; Risk Factors; Risk Reduction Behavior; Sedentary Behavior; Time Factors; Up-Regulation; Uric Acid; Uric Acid - blood; Young Adult; Republic of Korea; epidemiology; cardiovascular diseases; healthy lifestyle; uric acid
• ISSN: 1178-2048; 1176-6344; 1178-2048
• DOI: 10.2147/vhrm.s200278

A significant discovery was recently made in which participation in physical activity and sedentary behavior, two contrasting lifestyles, was found to be related to the frequency of hyperuricemia diagnosis. The purpose of this study was to identify the association between sedentary behavior and physical activity levels in South Korean men and women diagnosed with hyperuricemia. This study included 161,064 healthy men and women participants who had obtained a complete health examination. Physical activity levels and sitting time were assessed by the validated International Physical Activity Questionnaire Short Form Korean version. The presence of hyperuricemia in the subjects was determined by measuring serum uric acid (SUA) concentration (SUA ≥6 mg/dL [male], SUA ≥7 mg/dL [female]). Logistic regression analysis, adjusting other confounding factors, was conducted to identify the association of sedentary behavior and physical activity levels with hyperuricemia ( <0.05). Subjects who spent ≥10 hr/day in sedentary behavior were more likely to have hyperuricemia than those who spent <5 hour/day in sedentary behavior (OR=1.08, 95% CI=1.03-1.12). The subject group that more frequently participated in health enhanced physical activity (HEPA) had a lower hyperuricemia odds ratio than the subject group with lower physical activity participation rate (OR=0.90, 95% Ci=0.86-0.93). From the analysis of sex (male, female), age (young, middle, older), methods of measuring obesity (body mass index, waist circumference, body fat percentage), the association of sedentary behavior and physical activity levels with hyperuricemia was shown differently in different multivariable models. Participation in regular physical activity and reduced sedentary time is highly recommended in order to reduce the prevalence of hyperuricemia.