Effect of Lactobacillus plantarum LMT1-48 on Body Fat in Overweight Subjects: A Randomized, Double-Blind, Placebo-Controlled Trial

• Published in: Diabetes & metabolism journal Vol. 47; no. 1; pp. 92 - 103
• Main Authors: Sohn, Minji, Jung, Hyeyoung, Lee, Woo Shun, Kim, Tai Hoon, Lim, Soo
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Diabetes Association / Daehan Dangnyobyeong Hakoe 01.01.2023; Korean Diabetes Association; 대한당뇨병학회
• Subjects: Abdomen; Adipose Tissue; Body fat; Body Weight; Cardiovascular disease; Chronic illnesses; Diabetes; Fatty acids; Feces; Gastrointestinal surgery; Glucagon; Health care; Humans; Insulin Resistance; Lactobacillus plantarum; Leptin - therapeutic use; Obesity; Original; Overweight; Overweight - drug therapy; Peptides; Probiotics; Taxonomy; Weight control; 내과학; South Korea; Seoul South Korea; United States > US; Japan; Germany; Adiposity; Obesity; Lactobacillus plantarum
• ISSN: 2233-6079; 2233-6087; 2233-6087
• DOI: 10.4093/dmj.2021.0370

Background: We investigated whether Lactobacillus plantarum strain LMT1-48, isolated from Korean fermented foods and newborn feces, is a suitable probiotic supplement to treat overweight subjects.Methods: In this randomized, double-blind, placebo-controlled clinical trial, 100 volunteers with a body mass index of 25 to 30 kg/m2 were assigned randomly (1:1) to receive 2×1010 colony forming units of LMT1-48 or to a placebo treatment group. Body composition was measured by dual-energy X-ray absorptiometry, and abdominal visceral fat area (VFA) and subcutaneous fat area were measured by computed tomography scanning. Changes in body fat, VFA, anthropometric parameters, and biomarkers were compared between the two treatment groups (ClinicalTrials.gov number: NCT03759743).Results: After 12 weeks of treatment, the body weight decreased significantly from 76.6±9.4 to 75.7±9.2 kg in the LMT1-48 group but did not change in the placebo group (P=0.022 between groups). A similar pattern was found in abdominal VFA between the two groups (P=0.041). Serum insulin levels, the corresponding homeostasis model assessment of insulin resistance, and leptin levels decreased in the LMT1-48 group but increased in the placebo group (all P<0.05). Decrease in body weight and body mass index by treatment with LMT1-48 was correlated with increase in Lactobacillus levels significantly. LMT1-48 also increased Oscillibacter levels significantly, which were negatively correlated with triglyceride and alanine transaminase levels.Conclusion: Administration of LMT1-48 decreased body weight, abdominal VFA, insulin resistance, and leptin levels in these subjects with overweight, suggesting its anti-obesogenic therapeutic potential.