Multifunctional Trackable Dendritic Scaffolds and Delivery Agents

Dual action: Trackable multifunctional dendritic scaffolds with high internal loading capacity were synthesized based on a PEG core. Orthogonal functionalization of chain‐end and internal groups allowed the dendrimers to be both labeled and loaded with releasable dyes for simultaneous monitoring of...

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Published inAngewandte Chemie (International ed.) Vol. 50; no. 15; pp. 3425 - 3429
Main Authors Amir, Roey J., Albertazzi, Lorenzo, Willis, Jenny, Khan, Anzar, Kang, Taegon, Hawker, Craig J.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 04.04.2011
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
EditionInternational ed. in English
Subjects
click chemistry
Coumarins - chemistry
delivery platforms
dendrimers
Dendrimers - chemistry
Drug Delivery Systems
dye tracking
fluorescence microscopy
Molecular Structure
Spectrometry, Fluorescence
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Summary:Dual action: Trackable multifunctional dendritic scaffolds with high internal loading capacity were synthesized based on a PEG core. Orthogonal functionalization of chain‐end and internal groups allowed the dendrimers to be both labeled and loaded with releasable dyes for simultaneous monitoring of the dendritic carrier and release of the dye payload inside living cells (see picture).
Bibliography:National Institutes of Health - No. HHSN268201000046C
ark:/67375/WNG-D8SDG6C0-R
istex:8D1E1DED7C7D24F297BA367B67874BD2F513E341
ArticleID:ANIE201007427
National Science Foundation - No. DMR 05-20415
This work was supported by the National Institutes of Health as a Program of Excellence in Nanotechnology (HHSN268201000046C), by the MRSEC Program of the National Science Foundation through the MRL Central Facilities, by the Research Experience for Teachers program (DMR 05-20415), and through a Samsung fellowship (T.K.).
This work was supported by the National Institutes of Health as a Program of Excellence in Nanotechnology (HHSN268201000046C), by the MRSEC Program of the National Science Foundation through the MRL Central Facilities, by the Research Experience for Teachers program (DMR 05‐20415), and through a Samsung fellowship (T.K.).
These authors contributed equally to this work.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201007427