IN VITRO ACTIONS OF SOME ANTIBIOTICS ON PHOSPHOLIPASES

The effects of some antibiotics on activities of phospholipase A2, B and C were investigated in vitro. Tetracyclines, macrolides, chloramphenicol and carbenicillin inhibited the activity of Crotalus adamanteus phospholipase A2 towards phospholipids of egg-yolk emulsions. When the ability to inhibit...

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Bibliographic Details
Published inJournal of antibiotics Vol. 32; no. 7; pp. 734 - 739
Main Authors SUGATANI, JUNKO, SAITO, KUNIHIKO, HONJO, ICHIO
Format Journal Article
LanguageEnglish
Published Japan JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1979
Subjects
Carbenicillin - pharmacology
Chloramphenicol - pharmacology
Depression, Chemical
Lysophospholipase - metabolism
Phospholipases - metabolism
Phospholipases A - metabolism
Phospholipases A2
Tetracyclines - pharmacology
Type C Phospholipases - metabolism
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Summary:The effects of some antibiotics on activities of phospholipase A2, B and C were investigated in vitro. Tetracyclines, macrolides, chloramphenicol and carbenicillin inhibited the activity of Crotalus adamanteus phospholipase A2 towards phospholipids of egg-yolk emulsions. When the ability to inhibit the activity of Penicillium notatum phospholipase B towards mixed micelles of phosphatidylcholine and Triton X-100 was investigated, polymyxin B was found to be inhibitory while chloramphenicol and carbenicillin were found to stimulate the activity of the phospholipase. The activity of Bacillus cereus phospholipase C towards the mixed micelles was inhibited by bleomycin, oleandomycin and chloramphenicol.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.32.734