Antioxidant Enzyme Activity in Rat Hippocampus after Chronic and Acute Stress Exposure

• Published in: Annals of the New York Academy of Sciences Vol. 1048; no. 1; pp. 373 - 376
• Main Authors: Stojiljkovic, Vesna, Todorovic, Ana, KASAPOVIC, JELENA, Pejic, Snezana, PAJOVIC, SNEZANA B
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.2005
• Subjects: Adaptation; Animals; Antioxidants; Antioxidants - analysis; Antioxidants - metabolism; Brain; Catalase; Catalase - analysis; Catalase - metabolism; Enzyme Activation; Enzyme activity; Hippocampus; Hippocampus - enzymology; Human; Oxidative Stress - physiology; rat; Rats; Rats, Wistar; stress; Stresses; superoxide dismutase; Superoxide Dismutase - analysis; Superoxide Dismutase - metabolism
• ISSN: 0077-8923; 1749-6632
• DOI: 10.1196/annals.1342.042

: Chronic exposure to stress alters the prooxidant‐antioxidant balance, which might lead to the development of various human pathological states. In order to explain the role of antioxidant response in stress‐induced injury, we examined the effects of two types of acute stress, as well as combined effects of chronic and acute stress on manganese‐superoxide dismutase, copper, zinc‐superoxide dismutase, and catalase activities in rat brain hippocampus. Our results show that chronic stress induces an increase in oxidative enzyme activities and that adaptation to chronic stress might alter hippocampal antioxidant mechanisms' response to acute stress.