Preliminary report: A serious link between adiponectin levels and metabolic syndrome in a Korean nondiabetic population

• Published in: Metabolism, clinical and experimental Vol. 59; no. 3; pp. 333 - 337
• Main Authors: Koh, Sang-Back, Park, Jong-Ku, Yoon, Jin-Ha, Chang, Sei-Jin, Oh, Sung-Soo, Kim, Jang-Young, Ryu, So-Yeon, Kim, Ki-Soon, Lee, Tae-Yong, You, Joshua (Sung) H
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.03.2010; Elsevier
• Subjects: Adiponectin - blood; Aged; Anthropometry; Biological and medical sciences; Biomarkers; Blood Glucose - metabolism; Body Mass Index; Cohort Studies; Endocrinology & Metabolism; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Homeostasis; Humans; Insulin Resistance; Lipids - blood; Logistic Models; Male; Medical sciences; Metabolic diseases; Metabolic Syndrome - blood; Metabolic Syndrome - epidemiology; Middle Aged; Miscellaneous; Other metabolic disorders; Phenotype; Republic of Korea - epidemiology; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Asia; Korea; Endocrinopathy; Metabolic diseases; Cardiovascular disease; Metabolic syndrome; Endocrinology; Adiponectin
• ISSN: 0026-0495; 1532-8600
• DOI: 10.1016/j.metabol.2009.07.031

Abstract This large-scale cross-sectional investigation highlights the relationships between adiponectin levels and a number of metabolic syndrome components in a nondiabetic Korean population (N = 6634). In a multivariate logistic regression model, after adjustment for age, homeostasis model assessment of insulin resistance, body mass index, smoking history, C-reactive protein, and low-density lipoprotein cholesterol, adiponectin levels were inversely related with metabolic syndrome in men and women ( P < .05). Adiponectin level was found to be a significant contributor to metabolic syndrome. Our findings suggest that adiponectin is an important biomarker even in a nondiabetic population at high risk of metabolic syndrome.