Quinolone Arthropathy in Animals Versus Children

• Published in: Clinical infectious diseases Vol. 25; no. 5; pp. 1196 - 1204
• Main Authors: Burkhardt, John E., Walterspiel, Juan N., Schaad, Urs B.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01.11.1997; University of Chicago Press
• Subjects: Adolescent; Adolescents; Age Factors; Animals; Arthralgia - chemically induced; Articular cartilage; Biological and medical sciences; Cartilage; Cartilage - drug effects; Child; Children; Clinical Articles; Cystic fibrosis; Dosage; Drug toxicity and drugs side effects treatment; Growth; Humans; Infections; Joint Diseases - chemically induced; Joint Diseases - physiopathology; Joints; Medical sciences; Pharmacokinetics; Pharmacology. Drug treatments; Quinolones; Quinolones - adverse effects; Quinolones - pharmacology; Toxicity: osteoarticular system; Human; Toxicity; Diseases of the osteoarticular system; Bibliographic survey; Antibiotic; Articular cartilage; Animal; Arthropathy; Pharmacokinetics; Child; Age; Comparative study; Quinolone derivatives
• ISSN: 1058-4838; 1537-6591
• DOI: 10.1086/516119

The use of quinolones in children and accumulation of data on the pharmacodynamics of these drugs have been limited and delayed by concern regarding their chondrotoxicity. A comprehensive review of the findings in animals compared with the cumulative published findings in children and adolescents (>7,000 to date) allows the conclusion that such concern is not justified. Prospective controlled studies in children are justifiable in view of a continuing lack of correlation between findings in juvenile animals and those in children and because of the selected therapeutic advantages of the current and newer quinolones.