Quinolone Arthropathy in Animals Versus Children
The use of quinolones in children and accumulation of data on the pharmacodynamics of these drugs have been limited and delayed by concern regarding their chondrotoxicity. A comprehensive review of the findings in animals compared with the cumulative published findings in children and adolescents (&...
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Published in | Clinical infectious diseases Vol. 25; no. 5; pp. 1196 - 1204 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Chicago, IL
The University of Chicago Press
01.11.1997
University of Chicago Press |
Subjects | |
Online Access | Get full text |
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Summary: | The use of quinolones in children and accumulation of data on the pharmacodynamics of these drugs have been limited and delayed by concern regarding their chondrotoxicity. A comprehensive review of the findings in animals compared with the cumulative published findings in children and adolescents (>7,000 to date) allows the conclusion that such concern is not justified. Prospective controlled studies in children are justifiable in view of a continuing lack of correlation between findings in juvenile animals and those in children and because of the selected therapeutic advantages of the current and newer quinolones. |
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Bibliography: | Reprints or correspondence: Dr. John E. Burkhardt, Pfizer, Inc., Eastern Point Road, Groton, Connecticut 06340. istex:CDA8C03CB284E9D9043D82EE63DBD479F832AA03 ark:/67375/HXZ-LMGF6ZQN-V ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 1058-4838 1537-6591 |
DOI: | 10.1086/516119 |