Nonalcoholic fatty liver disease is an independent risk factor for ischemic stroke after revascularization in patients with Moyamoya disease: a prospective cohort study

• Published in: Lipids in health and disease Vol. 23; no. 1; p. 80
• Main Authors: Zhang, Bojian, Li, Junsheng, Zeng, Chaofan, Tao, Chuming, He, Qiheng, Liu, Chenglong, Zheng, Zhiyao, Zhao, Zhikang, Mou, Siqi, Sun, Wei, Wang, Jia, Zhang, Qian, Wang, Rong, Zhang, Yan, Ge, Peicong, Zhang, Dong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.03.2024; BioMed Central; BMC
• Subjects: Alcoholism; Care and treatment; Cerebral revascularization; Cerebral Revascularization - adverse effects; Cerebral Revascularization - methods; Comparative analysis; Complications and side effects; Development and progression; Diabetes; Fatty liver; Health aspects; Humans; Hypertension; Ischemia; Ischemic Stroke - complications; Liver diseases; Medical imaging; Medical prognosis; Medical research; Medicine, Experimental; Moyamoya disease; Moyamoya Disease - complications; Moyamoya Disease - diagnostic imaging; Moyamoya Disease - surgery; NAFLD; Non-alcoholic Fatty Liver Disease - complications; Patients; Prognosis; Prospective Studies; Regression analysis; Retrospective Studies; Risk factor; Risk Factors; Spleen; Stroke; Stroke (Disease); Stroke - complications; Stroke patients; Surgical outcomes; Treatment Outcome; Ultrasonic imaging; Ultrasound imaging; Veins & arteries; China; NAFLD; Stroke; Moyamoya disease; Prognosis; Risk factor
• ISSN: 1476-511X; 1476-511X
• DOI: 10.1186/s12944-024-02065-5

The study aimed to investigate the association between nonalcoholic fatty liver disease (NAFLD) and ischemic stroke events after revascularization in patients with Moyamoya disease (MMD). This study prospectively enrolled 275 MMD patients from September 2020 to December 2021. Patients with alcoholism and other liver diseases were excluded. NAFLD was confirmed by CT imaging or abdominal ultrasonography. Stroke events and modified Rankin Scale (mRS) scores at the latest follow-up were compared between the two groups. A total of 275 patients were enrolled in the study, among which 65 were diagnosed with NAFLD. Univariate logistic regression analysis showed that NAFLD (P = 0.029) was related to stroke events. Multivariate logistic regression analysis showed that NAFLD is a predictor of postoperative stroke in MMD patients (OR = 27.145, 95% CI = 2.031-362.81, P = 0.013). Kaplan-Meier analysis showed that compared with MMD patients with NAFLD, patients in the control group had a longer stroke-free time (P = 0.004). Univariate Cox analysis showed that NAFLD (P = 0.016) was associated with ischemic stroke during follow-up in patients with MMD. Multivariate Cox analysis showed that NAFLD was an independent risk factor for stroke in patients with MMD (HR = 10.815, 95% CI = 1.259-92.881, P = 0.030). Furthermore, fewer patients in the NAFLD group had good neurologic status (mRS score ≤ 2) than the control group (P = 0.005). NAFLD was an independent risk factor for stroke in patients with MMD after revascularization and worse neurological function outcomes.