Second primary malignancies in patients with male breast cancer

An international multicentre study of first and second primary neoplasms associated with male breast cancer was carried out by pooling data from 13 cancer registries. Among a total of 3409 men with primary breast cancer, 426 (12.5%) developed a second neoplasia; other than breast cancer, a 34% overa...

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Bibliographic Details
Published inBritish journal of cancer Vol. 92; no. 7; pp. 1288 - 1292
Main Authors HEMMINKI, K, SCELO, G, CHIA, K.-S, POMPE-KIRN, V, MARTOS, C, JONASSON, J. G, LI, X, BRENNAN, P, BOFFETTA, P, MELLEMKJAER, L, TRACEY, E, ANDERSEN, A, BREWSTER, D. H, PUKKALA, E, MCBRIDE, M, KLIEWER, E. V
Format Journal Article
LanguageEnglish
Published Basingstoke Nature Publishing Group 11.04.2005
Subjects
Adult
Aged
Biological and medical sciences
Breast cancer
Breast Neoplasms, Male - complications
Epidemiology
Follow-Up Studies
Humans
Incidence
Male
Medical sciences
Medicin och hälsovetenskap
Middle Aged
Neoplasms, Second Primary - epidemiology
Neoplasms, Second Primary - etiology
Registries - statistics & numerical data
Risk Factors
Tumors
Human
cancer registry
subsequent malignancy
Patient
Male
BRCA in men
Malignancy
Breast cancer
Malignant tumor
Mammary gland diseases
pooled analysis
Cancerology
Register
Second cancer
Primary
Adult
discordant sites
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Summary:An international multicentre study of first and second primary neoplasms associated with male breast cancer was carried out by pooling data from 13 cancer registries. Among a total of 3409 men with primary breast cancer, 426 (12.5%) developed a second neoplasia; other than breast cancer, a 34% overall excess risk of second primary neoplasia, affecting the small intestine (standardised incidence ratio, 4.95, 95% confidence interval, 1.35-12.7), rectum (1.78, 1.20-2.54), pancreas (1.93, 1.14-3.05), skin (nonmelanoma, 1.65, 1.16-2.29), prostate (1.61, 1.34-1.93) and lymphohaematopoietic system (1.63, 1.12-2.29). A total of 225 male breast cancers was recorded after cancers other than breast cancer, but an increase was found only after lymphohaematopoietic neoplasms. BRCA2 (and to some extent BRCA1) mutations may explain the findings for pancreatic and prostate cancers. Increases at other sites may be related to unknown factors or to chance. This large study shows that the risks for second discordant tumours after male breast cancer pose only a moderate excess risk.
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ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6602505