Association of the triglyceride-glucose index with early-onset atherosclerotic cardiovascular disease events and all-cause mortality: a prospective cohort study

• Published in: Cardiovascular diabetology Vol. 23; no. 1; p. 149
• Main Authors: Hou, Qiqi, Qi, Qi, Han, Quanle, Yu, Jie, Wu, Jianmei, Yang, Hui, Chen, Shuohua, Wu, Shouling, Li, Kangbo
• Format: Journal Article
• Language: English
• Published: England BioMed Central 29.04.2024; BMC
• Subjects: Adult; Age; Age of Onset; All-cause mortality; Antihypertensives; Arteriosclerosis; Atherosclerosis; Atherosclerosis - blood; Atherosclerosis - diagnosis; Atherosclerosis - epidemiology; Atherosclerosis - mortality; Atherosclerotic cardiovascular disease events; Biomarkers - blood; Blood Glucose - analysis; Blood Glucose - metabolism; Blood pressure; Body mass index; Cardiovascular disease; Cardiovascular diseases; Cause of Death; China - epidemiology; Cholesterol; Cohort analysis; Diabetes; Female; Glucose; High density lipoprotein; Humans; Hypertension; Incidence; Male; Males; Middle age; Middle Aged; Mortality; North China; Prognosis; Prospective Studies; Risk Assessment; Risk Factors; Sensitivity analysis; Smoking; Stroke; Time Factors; Trends; Triglyceride glucose index; Triglycerides - blood; Young adults; Young and middle-aged people; China; North China; Triglyceride glucose index; Atherosclerotic cardiovascular disease events; All-cause mortality; Young and middle-aged people
• ISSN: 1475-2840; 1475-2840
• DOI: 10.1186/s12933-024-02249-4

The association between the triglyceride glucose (TyG) index and the risk of early-onset atherosclerotic cardiovascular disease (ASCVD) events or all-cause mortality in young and middle-aged people is not fully elucidated. The present study included 64,489 young and middle-aged people who participated in the 2006 Kailuan Study physical examination. Multivariate Cox proportional hazards models and restricted cubic spline curves were used to assess the association of TyG index with early-onset ASCVD events and all-cause mortality. During a median of 11-year follow-up, 1984 (3.08%) participants experienced at least one ASCVD event and 1,392 (2.16%) participants experienced all-cause death. A higher TyG index was significantly associated with a higher risk of early-onset ASCVD events (HR: 1.61, 95% CI 1.38-1.89) and all-cause mortality (HR: 1.39, 95% CI 1.17-1.65), respectively. For each unit increase in TyG index, the risk of early-onset ASCVD events increased by 20%. In addition, there was a non-linear association between the TyG index and early-onset ASCVD events (P for non-linear < 0.01), and a linear association between TyG index and all-cause mortality (P for non-linear = 0.476). A higher TyG index is significantly associated with an increased incidence of early-onset ASCVD events and all-cause mortality in a young and middle-aged population from North China.