Ovarian hyperstimulation and oophorectomy following accidental daily clomiphene citrate use over three consecutive months

We describe the longest-known continuous use of clomiphene citrate ever reported in a human. As a result of a pharmacy error, a woman took 50 mg/day clomiphene citrate for three months. The prolonged use of this medication resulted in ovarian hyperstimulation and unilateral oophorectomy for torsion.

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Bibliographic Details
Published inReproductive toxicology (Elmsford, N.Y.) Vol. 14; no. 6; pp. 541 - 543
Main Authors Sills, E.Scott, Poynor, Elizabeth A, Moomjy, Maureen
Format Journal Article Conference Proceeding
LanguageEnglish
Published New York, NY Elsevier Inc 2000
Elsevier
Subjects
Adult
Biological and medical sciences
Clomiphene - adverse effects
clomiphene citrate
Clomiphene toxicity
Drug intoxications. Doping
Female
Fertility Agents, Female - adverse effects
Hormone Replacement Therapy
Humans
Medical sciences
Medication error
Medication Errors
Oophorectomy
Ovarian Hyperstimulation Syndrome - chemically induced
Ovarian Hyperstimulation Syndrome - pathology
Ovariectomy
ovaries
Ovary - diagnostic imaging
Ovary - drug effects
Ovary - pathology
Ovary - surgery
Pharmacology. Drug treatments
Thyroxine - therapeutic use
Tomography, X-Ray Computed
Torsion
Medication error
Clomiphene toxicity
Oophorectomy
Torsion
Human
Non steroidal estrogen
Toxicity
Drug intoxication
Clomifene
Long term
Female genital diseases
Human error
Case study
Ovary
Chronic
Accident
Female
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Summary:We describe the longest-known continuous use of clomiphene citrate ever reported in a human. As a result of a pharmacy error, a woman took 50 mg/day clomiphene citrate for three months. The prolonged use of this medication resulted in ovarian hyperstimulation and unilateral oophorectomy for torsion.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0890-6238
1873-1708
DOI:10.1016/S0890-6238(00)00103-9