Non-coding RNA in endothelial-to-mesenchymal transition

Abstract Endothelial-to-mesenchymal transition (EndMT) is the process wherein endothelial cells lose their typical endothelial cell markers and functions and adopt a mesenchymal-like phenotype. EndMT is required for development of the cardiac valves, the pulmonary and dorsal aorta, and arterial matu...

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Bibliographic Details
Published inCardiovascular research Vol. 115; no. 12; pp. 1716 - 1731
Main Authors Hulshoff, Melanie S, del Monte-Nieto, Gonzalo, Kovacic, Jason, Krenning, Guido
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.10.2019
Subjects
Review Series from the 3rd Joint ESM-EVBO Conference 2019
Cardiac development
Cardiovascular disease
Non-coding RNA
Endothelial-mesenchymal transition (EndMT)
Plasticity
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Summary:Abstract Endothelial-to-mesenchymal transition (EndMT) is the process wherein endothelial cells lose their typical endothelial cell markers and functions and adopt a mesenchymal-like phenotype. EndMT is required for development of the cardiac valves, the pulmonary and dorsal aorta, and arterial maturation, but activation of the EndMT programme during adulthood is believed to contribute to several pathologies including organ fibrosis, cardiovascular disease, and cancer. Non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, modulate EndMT during development and disease. Here, we review the mechanisms by which non-coding RNAs facilitate or inhibit EndMT during development and disease and provide a perspective on the therapeutic application of non-coding RNAs to treat fibroproliferative cardiovascular disease.
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Melanie S. Hulshoff and Gonzalo del Monte-Nieto contributed equally to the study.
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/cvz211