Cut-off value for interleukin-34 as an additional potential inflammatory biomarker for estimation of slow coronary flow risk

• Published in: BMC cardiovascular disorders Vol. 24; no. 1; p. 2
• Main Authors: Karasu, Mehdi, Bolayır, Hasan Ata
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 02.01.2024; BioMed Central; BMC
• Subjects: Angina pectoris; Angiography; Arteriosclerosis; Atherosclerosis; Automation; Biological markers; Biomarkers; Blood; Blood Flow Velocity; C-Reactive Protein; Cardiac patients; Cardiomyopathy; Cardiovascular disease; Cholesterol; Coronary Angiography; Coronary artery disease; Coronary Circulation - physiology; Coronary heart disease; Coronary vessels; Cross-Sectional Studies; Cytokines; Development and progression; Endothelium; Flow velocity; Health aspects; Heart attacks; Heart diseases; Heart failure; Hibernation; High density lipoprotein; hsCRP; Humans; Identification and classification; IL-34; Inflammation; Inflammatory diseases; Interleukins; Interleukins - blood; Interleukins - chemistry; Ischemia; Lipoproteins; Medical imaging; Mortality; Patients; Plasma; Proteins; Regression analysis; Slow coronary flow (SCF); Standard deviation; Statistical analysis; Turkey; hsCRP; IL-34; Slow coronary flow (SCF)
• ISSN: 1471-2261; 1471-2261
• DOI: 10.1186/s12872-023-03677-y

Inflammatory markers may provide insights into the underlying mechanisms of slow coronary flow (SCF), including subclinical atherosclerosis and endothelial dysfunction. Interleukin-34 (IL-34), known for its role in immuno-inflammatory diseases, might hold significance in SCF. We aimed to explore the potential association between IL-34 and SCF in patients undergoing diagnostic elective coronary angiography. This observational, cross-sectional study enrolled 256 participants: 124 with SCF and 132 with normal coronary flow (NCF). All participants had undergone outpatient coronary angiography for suspected coronary artery disease. SCF assessment employed the TIMI frame count (TFC) for quantifying coronary flow rate. SCF patients exhibited significantly elevated TFC in all three major coronary arteries compared to controls (p < 0.05). IL-34 displayed a noteworthy positive correlation with average TFC [for all participants: r = 0.514, p < 0.001; for SCF patients: r = 0.526, p < 0.001; for normal controls: r = -0.288, p > 0.05]. Similarly, high-sensitivity C-reactive protein (hsCRP) showed a significant and positive relationship with average TFC [for all participants: r = 0.504, p < 0.001; for SCF patients: r = 0.558, p < 0.001; for normal controls: r = -0.148, p > 0.05]. SCF patients presented coronary arteries of larger size compared to controls. Mean coronary diameter and IL-34 emerged as independent predictors of SCF. Additionally, hsCRP, mean coronary diameter, and IL-34 exhibited a positive correlation with mean TFC values. IL-34 appears to be a more effective indicator than hsCRP in SCF patients.