Nitric oxide: a new messenger in the brain

The important role played by nitric oxide (NO) in the central nervous system has largely been emphasized in the recent literature. It can originate at least from four different sources: the endothelium of cerebral vessels, the immunostimulated microglia and astrocytes, the nonadrenergic noncholinerg...

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Bibliographic Details
Published inNeuroscience and biobehavioral reviews Vol. 17; no. 4; p. 373
Main Authors Bruhwyler, J, Chleide, E, Liégeois, J F, Carreer, F
Format Journal Article
LanguageEnglish
Published United States 1993
Subjects
Animals
Brain - physiology
Humans
Neurotransmitter Agents - physiology
Nitric Oxide - physiology
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Summary:The important role played by nitric oxide (NO) in the central nervous system has largely been emphasized in the recent literature. It can originate at least from four different sources: the endothelium of cerebral vessels, the immunostimulated microglia and astrocytes, the nonadrenergic noncholinergic nerve, and the glutamate neuron. NO has been implicated in a large number of pathologies (such as neurotoxicity in Alzheimer's disease and Huntington's disease, cerebral ischemia, stroke, and anxiety) and also in normal physiological functions (such as memory and learning, regulation of the cerebrovascular system, modulation of the wakefulness, mediation of nociception, olfaction, food intake and drinking, regulation of noradrenaline, and dopamine release). The aim of this paper is to review and to integrate the most recent advances in our understanding of the roles of NO in the brain.
ISSN:0149-7634
DOI:10.1016/S0149-7634(05)80114-9