Specific change in spectral power of fetal heart rate variability related to fetal acidemia during labor: Comparison between preterm and term fetuses

• Published in: Early human development Vol. 88; no. 4; pp. 203 - 207
• Main Authors: Kwon, Ji Young, Park, In Yang, Shin, Jong Chul, Song, Juhee, Tafreshi, Reza, Lim, Jongil
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ireland Ltd 01.04.2012; Elsevier
• Subjects: Acidosis - complications; Acidosis - congenital; Acidosis - physiopathology; Adult; Advanced Basic Science; Biological and medical sciences; Cardiotocography; Cardiotocography - methods; Cardiovascular Diseases - congenital; Cardiovascular Diseases - diagnosis; Cardiovascular Diseases - etiology; Cardiovascular Diseases - physiopathology; Case-Control Studies; Embryology: invertebrates and vertebrates. Teratology; Female; Fetal acidemia; Fetal Monitoring - methods; Fundamental and applied biological sciences. Psychology; Gestational Age; Heart rate variability; Heart Rate, Fetal - physiology; Humans; Infant, Newborn; Infant, Newborn, Diseases - diagnosis; Infant, Newborn, Diseases - etiology; Infant, Newborn, Diseases - physiopathology; Infant, Premature - physiology; Infant, Premature, Diseases - etiology; Infant, Premature, Diseases - physiopathology; Male; Neonatal and Perinatal Medicine; Obstetric Labor Complications - diagnosis; Obstetric Labor Complications - physiopathology; Pregnancy; Spectral analysis; Term Birth; Umbilical arterial low pH; Fetal acidemia; Cardiotocography; Umbilical arterial low pH; Heart rate variability; Spectral analysis; Human; Pregnancy disorders; Variability; Premature delivery; Acidemia; Heart rate; Fetus; Comparative study
• ISSN: 0378-3782; 1872-6232; 1872-6232
• DOI: 10.1016/j.earlhumdev.2011.08.007

Spectral analysis of fetal heart rate (FHR) variability is a useful method to assess fetal condition. There have been several studies involving the change in spectral power related to fetal acidemia, but the results have been inconsistent. To determine the change in spectral power related to fetal umbilical arterial pH at birth, dividing cases into preterm (31–36weeks) and term (≥37weeks) gestations. Case–control study. The 514 cases of deliveries were divided into a low-pH group (an umbilical arterial pH <7.2) and a control group (pH≥7.2). FHR recorded on cardiotocography during the last 2h of labor. The spectral powers in various bands of FHR variability. In preterm fetuses, the total, low (LF), and movement (MF) frequency spectral powers and LF/HF ratio were significantly lower in the low-pH group than the control group (all P<0.05). In contrast, in term fetuses, the total frequency, LF, and MF powers were significantly higher in the low-pH group than the control group (all P<0.05). The area under the receiver operating characteristic of LF power to detect a low pH at birth was 0.794 in preterm fetuses and 0.595 in term fetuses. The specificity was 86.8% and 93.3% in preterm and term fetuses, respectively. The changes in spectral power responding to a low pH are different between term and preterm fetuses. Spectral analysis of FHR variability may be useful fetal monitoring for early detection of fetal acidemia.