Whole-brain dopamine transporter binding pattern predicts survival in multiple system atrophy

For quantitative analysis, we then generated "relative decrease” maps for three clusters – cluster 1, 3, and 4, using cluster 2 as a reference cluster due to its relatively intact DAT binding (Fig. 1e). Multivariate survival analysis indicated that the cluster model (HR 2.00 [1.33–3.01], P = 0....

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Published inTranslational neurodegeneration Vol. 13; no. 1; p. 18
Main Authors Kang, Yeon-Koo, Shin, Jung Hwan, Choi, Hongyoon, Kim, Han-Joon, Cheon, Gi Jeong, Jeon, Beomseok
Format Journal Article
LanguageEnglish
Published England BioMed Central 02.04.2024
BMC
Subjects
Age
Atrophy
Biomarkers
Brain - metabolism
Dopamine
Dopamine Plasma Membrane Transport Proteins - metabolism
Humans
Letter
Medical prognosis
Multiple System Atrophy - diagnostic imaging
Multiple System Atrophy - metabolism
Positron-Emission Tomography
Survival analysis
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Summary:For quantitative analysis, we then generated "relative decrease” maps for three clusters – cluster 1, 3, and 4, using cluster 2 as a reference cluster due to its relatively intact DAT binding (Fig. 1e). Multivariate survival analysis indicated that the cluster model (HR 2.00 [1.33–3.01], P = 0.001) and the BR of the brainstem (HR 0.07 [0.0083–0.63], P = 0.018) significantly predicted survival, with age, age at onset, sex, disease duration and disease subtype as cofactors (Additional file 1: The clustering model demonstrated independent prognostic predictive value, in contrast to traditional regional PET quantification parameters from the striatum, in predicting survival outcomes within the independent MSA cohort, as depicted in Table S5. [...]clinical rating scales like UMSAR (Unified multiple system atrophy rating scale) were not incorporated.
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ObjectType-Correspondence-1
ISSN:2047-9158
2047-9158
DOI:10.1186/s40035-024-00411-2