Male reproductive tract abnormalities: More common after assisted reproduction?

• Published in: Early human development Vol. 86; no. 9; pp. 547 - 550
• Main Authors: Funke, Simone, Flach, Edina, Kiss, István, Sándor, János, Vida, Gabriella, Bódis, József, Ertl, Tibor
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ireland Ltd 01.09.2010; Elsevier
• Subjects: Advanced Basic Science; Assisted reproduction; Biological and medical sciences; Cohort Studies; Embryology: invertebrates and vertebrates. Teratology; Female; Fertilization in Vitro - adverse effects; Fundamental and applied biological sciences. Psychology; Humans; Hungary; Hypospadias - etiology; Infant, Low Birth Weight; Infant, Newborn; Male; Male reproductive tract abnormalities; Neonatal and Perinatal Medicine; Pregnancy; Pregnancy, Multiple; Premature Birth; Risk Factors; Semen Analysis; Testicular Diseases - etiology; Testicular dysgenesis syndrome; Hungary; Assisted reproduction; Testicular dysgenesis syndrome; Male reproductive tract abnormalities; Human; Reproduction; Testicle; Male genital system
• ISSN: 0378-3782; 1872-6232; 1872-6232
• DOI: 10.1016/j.earlhumdev.2010.06.015

In this era of increased use of assisted reproduction (AR) techniques, the prevalence rates of hypospadias, cryptorchidism, poor semen quality have been increasing in parallel with a rising incidence of testicular cancer. It is suggested that these problems result from the disruption of gonadal development during fetal life causing the testicular dysgenesis syndrome (TDS). The aim of our study was to evaluate the influence of conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), on the development of male genital tract abnormalities. Study design and subjects: We analyzed a cohort of 15,206 neonates born from January 1, 1999 through December 31, 2008 at the Department of Obstetrics and Gynecology, Medical School, University of Pécs, including 890 children (5.9%) born after IVF or ICSI. We examined the association between these AR methods and developmental abnormalities of the genital tract (hypospadias, cryptorchidism), after controlling for potential confounding factors, such as prematurity, low birthweight and twinning. Preterm birth and low birthweight are risk factors for hypospadias and cryptorchidism (p<0.001), twinning increases the risk of hypospadias (p<0.001). ICSI was revealed as a risk factor for hypospadias in singletons (OR: 3.190, 95%CI: 1.266–8.042) and in normal birthweight (>2500g) infants (OR: 3.966, 95%CI: 1.193–13.181, respectively). Similar but not nonsignificant trends were seen for cryptorchidism. IVF and ICSI, by increasing the risks of prematurity, low birthweight, and multiple gestation, are indirect risk factors for developing male genital malformations. In infants with normal birhtweight or from singleton pregnancies, ICSI is a specific risk factor for hypospadias.