The clinical and pathological characteristics of lipid-rich carcinoma of the breast: an analysis of 98 published patients

• Published in: BMC women's health Vol. 23; no. 1; p. 301
• Main Authors: Zhang, Mengdi, Pu, Dongqing, Shi, Guangxi, Li, Jingwei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 08.06.2023; BioMed Central; BMC
• Subjects: Age; Breast cancer; Breast Neoplasms - diagnosis; Breast Neoplasms - pathology; Breast Neoplasms - therapy; Cancer; Carcinoma - pathology; Care and treatment; Chemotherapy; Chemotherapy, Adjuvant; Clinical features; Development and progression; Diagnostic errors; Epidemiology; Female; Humans; Lipid-rich carcinoma; Lipids; Lymphatic metastasis; Lymphatic system; Mastectomy; Medical prognosis; Metastasis; Methods; Middle Aged; Mortality; Neoplasm Staging; Normal distribution; Pathology; Patient outcomes; Patients; Prevention; Prognosis; Radiation therapy; Retrospective Studies; Risk factors; Sample size; Surgery; Tumors; Womens health; China; United States > US; Asia; Pathology; Clinical features; Breast cancer; Lipid-rich carcinoma; Epidemiology
• ISSN: 1472-6874; 1472-6874
• DOI: 10.1186/s12905-023-02449-2

Due to the small number of cases and few literature reports, the clinical treatment and prognosis of lipid-rich carcinoma of the breast are not summarized, which will lead to misdiagnosis and mistreatment and delay the patient's condition. This study collected published case reports and analyzed the clinical characteristics of lipid-rich carcinoma of the breast in order to provide reference for early diagnosis and treatment of the disease. We performed a search using the PubMed, ClinicalTrials.gov, Embase, Cochrane Library, and China National Knowledge Infrastructure (CNKI) databases for publicly published case reports of lipid-rich carcinoma of the breast and obtained basic information of the patients such as country, age, sex, onset site, surgical method, pathology, postoperative treatment, follow-up time, and outcome (Table 9). The data were analyzed using Statistical Product Service Solutions (SPSS). The mean age of the patients at diagnosis was 52.79 years and the median age was 53 years. Breast masses were the main clinical manifestations, with the upper outer quadrant (53.42%) being the most common. The treatment for lipid-rich carcinoma of the breast is mainly surgery plus postoperative adjuvant radiotherapy and chemotherapy. According to the results of this study, the surgical method recommended modified radical mastectomy (46.59%). Lymph node metastasis was found in 50.60% of the patients at the time of the first diagnosis. Patients who received postoperative adjuvant chemotherapy and radiotherapy had the highest disease-free survival and overall survival. Lipid-rich carcinoma of the breast has a short course of disease and early lymphatic or blood metastasis, and its prognosis is poor. In this study, we summarize the clinical and pathological characteristics to provide ideas for the early diagnosis and treatment of lipid-rich carcinoma of the breast.