Gastric anti-ulcer activity of several α, β-unsaturated carbonyl compounds in rats

The gastric cytoprotective activity of several molecules containing an alpha,beta-unsaturated carbonyl system is reported. We attributed this gastroprotective activity to the presence of a non-hindered Michael acceptor in the molecules assayed and suggested that the mechanism of protection would inv...

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Bibliographic Details
Published inBiological & pharmaceutical bulletin Vol. 23; no. 5; pp. 555 - 557
Main Authors MARIA, A. O. M, DONADEL, O, WENDEL, G. H, GUZMAN, J. A, GUERREIRO, E, GIORDANO, O. S
Format Journal Article
LanguageEnglish
Published Tokyo Maruzen 2000
Subjects
4-Butyrolactone - analogs & derivatives
4-Butyrolactone - chemistry
4-Butyrolactone - therapeutic use
Animals
Anti-Ulcer Agents - chemistry
Anti-Ulcer Agents - therapeutic use
Biological and medical sciences
Cyclopentanes - chemistry
Cyclopentanes - therapeutic use
Digestive system
Gastric Mucosa - drug effects
Medical sciences
Pharmacology. Drug treatments
Protective Agents - chemistry
Protective Agents - therapeutic use
Rats
Rats, Wistar
Stomach Ulcer - chemically induced
Stomach Ulcer - prevention & control
Structure-Activity Relationship
Carbonyl compounds
Stomach
Ethanol
Rat
Digestive system
Toxicity
Rodentia
Antiulcer agent
Biological activity
Vertebrata
Mammalia
Cytoprotector
Structure activity relation
Animal
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Summary:The gastric cytoprotective activity of several molecules containing an alpha,beta-unsaturated carbonyl system is reported. We attributed this gastroprotective activity to the presence of a non-hindered Michael acceptor in the molecules assayed and suggested that the mechanism of protection would involve, at least in part, a nucleophilic attack of the sulphydryl group of the gastric mucosa to the beta carbon of the Michael acceptors of the compounds assayed.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.23.555