Facilitatory effects of chronically administered citicoline on learning and memory processes in the dog

• Published in: Progress in neuro-psychopharmacology & biological psychiatry Vol. 22; no. 1; pp. 115 - 128
• Main Authors: Bruhwyler, Jacques, Liegeois, Jean-Francois, Geczy, Joseph
• Format: Journal Article Web Resource
• Language: English
• Published: Amsterdam Elsevier Inc 1998; Elsevier; Elsevier Science
• Subjects: Acoustic Stimulation; Analysis of Variance; Animals; Biological and medical sciences; CDP-choline; citicoline; Conditioning, Operant - drug effects; Cytidine Diphosphate Choline - pharmacology; dog; Dogs; Exploratory Behavior; Human health sciences; learning; Male; Medical sciences; memory; Memory - drug effects; Neuropharmacology; Nootropic Agents - pharmacology; opérant responding; Pharmacie, pharmacologie & toxicologie; Pharmacology. Drug treatments; Pharmacy, pharmacology & toxicology; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Reinforcement (Psychology); retrieval; Reward; Sciences de la santé humaine; temporal regulation; Time Factors; opérant responding; temporal regulation; memory; CDP-choline; citicoline; retrieval; learning; differential reinforcement of response duration; dog; cytidine (5') diphosphocholine; limited hold; Fissipedia; Memory retrieval; Carnivora; Citicoline; Memory; Instrumental conditioning; Cognition; Learning; Vertebrata; Mammalia; Acquisition process; Animal; Nootropic agent; Differential reinforcement; Dog; Pyrimidine nucleoside
• ISSN: 0278-5846; 1878-4216; 1878-4216
• DOI: 10.1016/S0278-5846(97)00183-8

1. 1. Citicoline (cytidine (5') diphosphocholine) has been shown to reverse aging-induced memory deficits, scopolamine-induced amnesia and nucleus basalis magnocellularis lesion-induced learning impairment. 2. 2. This study aimed to evaluate the effects of citicoline on learning and retrieval processes in a complex differential reinforcement of response duration schedule in normal dogs. 3. 3. The effects of citicoline on a stabilized performance were also measured in order to be able to differentiate specific memory effects from non specific influences on the motor, neuro-vegetative and motivational systems. 4. 4. The results demonstrate that citicoline can exert facilitatory effects on learning and memory but also on retrieval processes. The complete absence of effects on the stabilized performance and on the motor, neuro-vegetative and motivational systems constitutes arguments in favour of a selectivity of action on the memory processes.