Do patients with cN0 oral squamous cell carcinoma benefit from elective neck dissection? A large-scale population-based study

• Published in: BMC oral health Vol. 24; no. 1; p. 32
• Main Authors: Wu, Qiuyu, Xia, Yuanhang, Qiu, Ling, Wen, Shuqiong, Li, Qunxing, Gao, Xiang, Jiang, Wenrong, Wang, Tao, Ji, Ping, Ou, Zhanpeng
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.01.2024; BioMed Central; BMC
• Subjects: Age; Cancer; Carcinoma, Squamous Cell - surgery; Care and treatment; Chemotherapy; Clinical-nodal negative; Cohort Studies; Disease-specific survival; Elective neck dissection; Epidemiology; Head and Neck Neoplasms; Humans; Marital status; Medical prognosis; Metastasis; Mouth cancer; Mouth Neoplasms - surgery; Multiple subgroup analyses; Neck; Neck Dissection; Oral cancer; Oral carcinoma; Oral squamous cell carcinoma; Patient outcomes; Patients; Population studies; Population-based studies; Radiation; Radical neck dissection; Retrospective Studies; SEER database; Software; Squamous cell carcinoma; Squamous Cell Carcinoma of Head and Neck; Statistics; Surgery; Survival analysis; Tongue Neoplasms; Tumors; United States; SEER database; Disease-specific survival; Clinical-nodal negative; Multiple subgroup analyses; Elective neck dissection; Oral squamous cell carcinoma; Overall survival
• ISSN: 1472-6831; 1472-6831
• DOI: 10.1186/s12903-023-03632-5

The neck management of clinical-nodal negative (cN0) oral squamous cell carcinoma (OSCC) remains controversial. Elective neck dissection (END) and observation are the main strategies, but it is still not clear who could benefit the most from END. The purpose of this study was to clarify the potential clinical factors that affect the therapeutic value of END and to explore the actual characteristics associated with benefit from END. Patients with cN0 OSCC were identified in the SEER database from 2000 to 2019. 5-year Overall survival (OS) and disease-specific survival (DSS) were analyzed using the Kaplan‒Meier method, and the hazard ratios (HRs) for survival were estimated using the Cox regression model. Multiple subgroup analyses of DSS and OS among different factors, comparing END and No END, were performed. A total of 17,019 patients with cN0 OSCC were included. The basic survival analysis and Cox regression model showed that END increased the probability of 5-year DSS and OS and was an independent prognostic factor. However, among patients who underwent only primary tumor surgery, no significant differences were found between the END and No END groups in 5-year DSS (P = 0. 585) and OS (P = 0.465). Further subgroup analysis showed that primary sites and T stage, but not other factors, might influence the benefit of END. Significant differences were found for T1 (P < 0.001 for OS) and T2 (P = 0.001 for DSS and < 0.001 for OS) tongue squamous cell carcinoma (TSCC) but not for other primary tumor sites. This large-scale retrospective population-based cohort study suggests that not all patients with cN0 OSCC could benefit from END. Patients with cN0 TSCC are recommended to undergo END, especially with early-stage tumors.