The pattern of antiganglioside antibody reactivities producing myelinated nerve conduction block in vitro

• Published in: Journal of the neurological sciences Vol. 161; no. 2; pp. 163 - 168
• Main Authors: Arasaki, Keisuke, Kusunoki, Susumu, Kudo, Norio, Tamaki, Mitsuyuki
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 11.12.1998; Elsevier Science
• Subjects: Action Potentials - physiology; Adolescent; Adult; Animals; Anti-ganglioside antibody; Antigen-Antibody Reactions; Biological and medical sciences; Conduction block; Demyelinating Diseases - immunology; Evoked Potentials - physiology; Female; Fundamental and applied biological sciences. Psychology; Gangliosides - immunology; GD1b; GM1; Humans; In Vitro Techniques; Male; Middle Aged; Myelinated nerve fibers; Nerve Block; Nerve Fibers, Myelinated - immunology; Neural Conduction - immunology; Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ; Radiculopathy - immunology; Rat; Rats; Rats, Wistar; Vertebrates: nervous system and sense organs; Anti-ganglioside antibody; Conduction block; GM1; Rat; GD1b; Myelinated nerve fibers; Antibody; Pathogenesis; Rodentia; Blocking; Exploration; Myelinated nerve fiber; Experimental study; In vitro; Nerve conduction; Vertebrata; Mammalia; Ganglioside; Animal
• ISSN: 0022-510X; 1878-5883
• DOI: 10.1016/S0022-510X(98)00283-4

We studied the pattern of human antiganglioside antibody reactivities causing an acute conduction block in rat myelinated nerve fibers, using an in vitro preparation of the sciatic–tibial nerve. With the aid of complements, IgM antibodies reacting with the terminal disaccharide of galactose (β1–3) N-acetylgalactosamine produced the block. These findings may help us to understand the mechanism in which the conduction block occurs in neuropathies associated with antiganglioside antibodies.