Clinicopathologic features and prognosis of combined hepatocellular cholangiocarcinoma

• Published in: The American journal of surgery Vol. 189; no. 1; pp. 120 - 125
• Main Authors: Koh, Kwang Cheol, Lee, Hyuk, Choi, Moon Seok, Lee, Joon Hyoek, Paik, Seung Woon, Yoo, Byung Chul, Rhee, Jong Chul, Cho, Jae Won, Park, Cheol Keun, Kim, Hong Joo
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 2005; Elsevier; Elsevier Limited
• Subjects: Adult; Aged; Bile Ducts, Intrahepatic; Biological and medical sciences; Cancer; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - pathology; Cholangiocarcinoma; Cholangiocarcinoma - mortality; Cholangiocarcinoma - pathology; Clinical trials; Combined hepatocellular cholangiocarcinoma; Female; Gastroenterology. Liver. Pancreas. Abdomen; General aspects; Hepatitis; Hepatocellular carcinoma; Humans; Infections; Liver cancer; Liver Neoplasms - mortality; Liver Neoplasms - pathology; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Methods; Middle Aged; Multivariate analysis; Neoplasm Recurrence, Local - epidemiology; Older people; Prognosis; Recurrence; Statistical analysis; Survival; Tomography; Tumors; Korea; Recurrence; Hepatocellular carcinoma; Prognosis; Combined hepatocellular cholangiocarcinoma; Survival; Cholangiocarcinoma; Clinical form; Hepatic disease; Malignant tumor; Biliary tract disease; Medicine; Histopathology; Malignant cholangioma; Surgery; Digestive diseases
• ISSN: 0002-9610; 1879-1883
• DOI: 10.1016/j.amjsurg.2004.03.018

Clinicopathologic features and prognosis of combined hepatocellular cholangiocarcinoma (HCC-CC) have not been established. Data of patients who underwent surgical resection for HCC-CC were compared with those of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (CC) patients. The prevalence of hepatitis B positivity (54.0%) and that of cirrhosis (54.2%) in the HCC-CC group were of intermediate tendency between the HCC group and the CC group. The HCC-CC group presented with a higher prevalence of multiplicity and microvascular emboli and portal vein or hepatic vein invasion, but a lower prevalence of capsular formation compared with the other groups. One- and 3-year survival rates in the HCC-CC group (81.9% and 47.0%, respectively) were lower than those in the HCC group and higher than those in the CC group. The cumulative recurrence rates at 6 months and at 1 year in the HCC-CC group (25.0% and 33.3%, respectively) were higher than those in the HCC group and lower than those in the CC group. The HCC-CC group has distinct clinicopathologic features compared with the HCC or CC groups. In addition, the HCC-CC group has a prognosis that is better than the CC group but worse than the HCC group.