Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer

• Published in: Biomarkers Vol. 18; no. 7; pp. 573 - 579
• Main Authors: Chung, Hyunsoo, Cho, Hanbyoul, Perry, Candice, Song, Jaekyung, Ylaya, Kris, Lee, Heejeong, Kim, Jae-Hoon
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.11.2013; Taylor & Francis
• Subjects: Adult; Aged; Cervical cancer; Cervical Intraepithelial Neoplasia - metabolism; Cervical Intraepithelial Neoplasia - mortality; Cervical Intraepithelial Neoplasia - pathology; Disease-Free Survival; Down-Regulation; ERp57; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; immunohistochemistry; Kaplan-Meier Estimate; Middle Aged; Multivariate Analysis; Neoplasm Staging; Prognosis; Protein Disulfide-Isomerases - genetics; Protein Disulfide-Isomerases - metabolism; Protein Transport; survival; Tissue Array Analysis; tissue microarray; Uterine Cervical Neoplasms - metabolism; Uterine Cervical Neoplasms - mortality; Uterine Cervical Neoplasms - pathology; Young Adult
• ISSN: 1354-750X; 1366-5804
• DOI: 10.3109/1354750X.2013.827742

Abstract Objective: We investigated the clinical significance of ERp57 in the progression of cervical cancer. Methods: mRNA and protein expression of ERp57 in cervical neoplasias were examined. Results: ERp57 mRNA expression was significantly decreased in cervical cancers. Immunohistochemistry revealed that ERp57 expression in 123 cervical cancers was down-regulated compared to cervical intraepithelial neoplasias or normal tissues (p < 0.001). Low ERp57 expression was significantly associated with worse overall survival (HR = 12.19, p = 0.018). Conclusions: Low ERp57 expression independently predicts a poor outcome for patients with cervical cancer, supporting the notion that ERp57 may be a promising novel cancer target.