Pioneering Astaxanthin-Tumor Cell Membrane Nanoparticles for Innovative Targeted Drug Delivery on Melanoma

• Published in: International journal of nanomedicine Vol. 19; pp. 2395 - 2407
• Main Authors: Chang, Jui-Jen, Wang, Yi-Chen, Yang, Shu-Hui, Wu, Ju-Yu, Chang, Ming-Wei, Wang, Hui-Min David
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2024; Dove; Dove Medical Press
• Subjects: Antineoplastic Agents - pharmacology; Antioxidants; astaxanthin; Cell Membrane; Cell membranes; Drug delivery systems; Drug therapy; Drugs; Ethylenediaminetetraacetic acid; Health aspects; Humans; Melanoma; Melanoma - drug therapy; Metastasis; nanoparticle; Nanoparticles; Original Research; Skin cancer; Vehicles; Xanthophylls; Taiwan; melanoma; nanoparticle; astaxanthin
• ISSN: 1178-2013; 1176-9114; 1178-2013
• DOI: 10.2147/IJN.S439476

Recently, the use of the tumor or its secretions as drug carriers has gradually become popular, with the advantages of high biocompatibility and enhanced drug delivery to specific cells. Melanoma is the most malignant tumor of all skin cancers; it is the most metastatic and, therefore, the most difficult to treat. The main purpose of this study is to develop nanovesicles with tumor cell membrane secretion properties to encapsulate target substances to enhance the therapeutic effect of cancer. Astaxanthin was selected as an anticancer drug due to our previous research finding that astaxanthin has extremely high antioxidant, anti-ultraviolet damage, and anti-tumor properties. The manufacturing method of the astaxanthin nanovesicle carrier is to mix melanoma cells and astaxanthin in an appropriate ratio and then remove the genetic material and inflammatory factors of cancer cells by extrusion. In terms of results, after the co-culture of astaxanthin nanovesicles and melanoma cancer cells, it was confirmed that the ability of astaxanthin nanovesicles to inhibit the growth and metastasis of melanoma cancer cells was significantly better than the same amount of astaxanthin alone, and it had no effect on normal Human cells are also effective. There was no apparent harm on normal cells, indicating the ability of the vesicles to be selectively transported. Our findings illustrated the potential of astaxanthin nanovesicles as an anticancer drug.