Predictive Value of the Atherogenic Index of Plasma (AIP) for the Risk of Incident Ischemic Heart Disease among Non-Diabetic Koreans

• Published in: Nutrients Vol. 13; no. 9; p. 3231
• Main Authors: Kim, Julie J., Yoon, Jihyun, Lee, Yong-Jae, Park, Byoungjin, Jung, Dong-Hyuk
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 16.09.2021; MDPI
• Subjects: Adults; Angina pectoris; atherogenic index of plasma; Atherosclerosis; Blood pressure; Body mass; Body mass index; Body size; C-reactive protein; cardiometabolic risk; Cardiovascular disease; Cardiovascular diseases; Cholesterol; Cohort analysis; cohort study; Confidence intervals; Coronary artery disease; Diabetes; Diabetes mellitus; Fasting; Glucose; Health hazards; Health insurance; Health risks; Heart diseases; Hypertension; Ischemia; ischemic heart disease; Lipids; Lipoproteins; Metabolic syndrome; Physical activity; Plasma; Population; Regression analysis; Risk assessment; Risk factors; Statistical analysis; Triglycerides; United States > US
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu13093231

The atherogenic index of plasma (AIP), composed of triglycerides and high-density lipoprotein cholesterol, is a novel critical marker for assessing the risk of atherogenicity and cardiometabolic health. We aimed to prospectively study the association between AIP and incident ischemic heart disease (IHD) risk in a large cohort of non-diabetic Korean adults. Data were assessed from 17,944 participants without diabetes from the Health Risk Assessment Study (HERAS) and Korea Health Insurance Review and Assessment (HIRA) data. The participants were divided into four groups according to AIP quartiles, calculated as log (triglyceride/high-density lipoprotein cholesterol). We prospectively assessed hazard ratios (HRs) with 95% confidence intervals (CIs) for IHD using multivariate Cox proportional-hazard regression models over a 50-month period that followed the baseline survey. During the follow-up period, 332 participants (1.9%) developed IHD. HRs of IHD for AIP quartiles 2–4 were 1.58 (95% CI, 1.03–2.43), 1.82 (95% CI, 1.20–2.78), and 2.11 (95% CI, 1.37–3.24) after adjusting for age, sex, body mass index, smoking status, alcohol intake, physical activity, mean arterial blood pressure, fasting plasma glucose, high-sensitivity C-reactive protein level, and hypertension medication. Higher AIP levels may precede and predict the development of IHD in non-diabetic Korean adults.