The effect of maternal starvation on plasma insulin-like growth factor I concentrations in the late gestation ovine fetus
In view of the suggested relationship between substrate availability, fetal growth and circulating fetal IGF-I concentrations, we investigated the effect of maternal starvation on plasma IGF-I levels in the late gestation ovine fetus. Ten fetuses aged 125-130 d gestation were sampled daily from indw...
Saved in:
Published in | Pediatric research Vol. 27; no. 4; pp. 401 - 404 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Hagerstown, MD
Lippincott Williams & Wilkins
01.04.1990
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | In view of the suggested relationship between substrate availability, fetal growth and circulating fetal IGF-I concentrations, we investigated the effect of maternal starvation on plasma IGF-I levels in the late gestation ovine fetus. Ten fetuses aged 125-130 d gestation were sampled daily from indwelling arterial catheters. Ewes were starved for 72 h. Starvation was terminated with an intravenous infusion of 10% glucose to the ewe. Food was then replaced 4 h later. Fetal IGF-I concentrations fell from 176.1 +/- 15.2 ng/mL before starvation to 124.5 +/- 10.3 ng/mL after 72 h starvation (p less than 0.05, n = 10). The fall in IGF-I concentrations was reversed by 4 h of maternal glucose infusion. In five fetuses, where samples were obtained 24 h after terminating the starvation, fetal IGF-I concentrations were comparable to those seen before starvation (180.0 +/- 37.7 ng/mL). This study demonstrates that acute maternal starvation causes a reversible decrease in fetal plasma IGF-I levels. These studies suggest that nutrient and in particular glucose availability is a significant determinant of fetal IGF-I secretion and support the hypothesis that IGF-I may play a role in the regulation of fetal growth. |
---|---|
Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0031-3998 1530-0447 1530-0447 |
DOI: | 10.1203/00006450-199004000-00015 |