Albumin Nanoparticle-Based Drug Delivery Systems

• Published in: International journal of nanomedicine Vol. 19; pp. 6945 - 6980
• Main Authors: Qu, Na, Song, Ke, Ji, Yating, Liu, Mingxia, Chen, Lijiang, Lee, Robert, Teng, Lesheng
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2024; Dove; Dove Medical Press
• Subjects: Albumin; albumin nanoparticle; Albumins - administration & dosage; Albumins - chemistry; Animals; application; Drug Carriers - chemistry; drug delivery; Drug delivery systems; Drug Delivery Systems - methods; Drugs; fabrication; Humans; modification; Nanoparticle Drug Delivery System - chemistry; Nanoparticles - chemistry; Review; Vehicles; drug delivery; application; modification; fabrication; albumin nanoparticle
• ISSN: 1178-2013; 1176-9114; 1178-2013
• DOI: 10.2147/IJN.S467876

Nanoparticle-based systems are extensively investigated for drug delivery. Among others, with superior biocompatibility and enhanced targeting capacity, albumin appears to be a promising carrier for drug delivery. Albumin nanoparticles are highly favored in many disease therapies, as they have the proper chemical groups for modification, cell-binding sites for cell adhesion, and affinity to protein drugs for nanocomplex generation. Herein, this review summarizes the recent fabrication techniques, modification strategies, and application of albumin nanoparticles. We first discuss various albumin nanoparticle fabrication methods, from both pros and cons. Then, we provide a comprehensive introduction to the modification section, including organic albumin nanoparticles, metal albumin nanoparticles, inorganic albumin nanoparticles, and albumin nanoparticle-based hybrids. We finally bring further perspectives on albumin nanoparticles used for various critical diseases.