Spatial distribution and determinants of intermittent preventive treatment for malaria during pregnancy: a secondary data analysis of the 2019 Ghana malaria indicators survey

• Published in: BMC pregnancy and childbirth Vol. 24; no. 1; p. 379
• Main Authors: Ndayishimiye, Jean Claude, Teg-Nefaah Tabong, Philip
• Format: Journal Article
• Language: English
• Published: England BioMed Central 20.05.2024; BMC
• Subjects: Adolescent; Adult; Anemia; Antimalarials - therapeutic use; Birth weight; Data Analysis; Data collection; Determinants; Drug Combinations; Female; Ghana; Ghana - epidemiology; Health surveys; Households; Humans; Infections; Intermittent preventive treatment; Malaria; Malaria - epidemiology; Malaria - prevention & control; Malaria during pregnancy; Middle Aged; Population; Pregnancy; Pregnancy Complications, Parasitic - epidemiology; Pregnancy Complications, Parasitic - prevention & control; Premature birth; Prenatal Care - statistics & numerical data; Pyrimethamine - therapeutic use; Regions; Rural areas; Secondary Data Analysis; Spatial Analysis; Spatial distribution; Sulfadoxine - administration & dosage; Sulfadoxine - therapeutic use; Systematic review; Womens health; Young Adult; Ghana; Southeast Asia; West Africa; Determinants; Intermittent preventive treatment; Ghana; Malaria during pregnancy; Spatial distribution
• ISSN: 1471-2393; 1471-2393
• DOI: 10.1186/s12884-024-06566-0

Malaria during pregnancy is associated with poor maternal, foetal, and neonatal outcomes. To prevent malaria infection during pregnancy, the World Health Organization recommended the use of intermittent preventive therapy with sulfadoxine-pyrimethamine (IPTp-SP) in addition to vector control strategies. Although Ghana's target is to ensure that all pregnant women receive at least three (optimal) doses of SP, the uptake of SP has remained low; between 2020 and 2022, only 60% of pregnant women received optimal SP during their most recent pregnancy. This study sought to map the geospatial distribution and identify factors associated with SP uptake during pregnancy in Ghana. Secondary data analysis was conducted using the 2019 Ghana Malaria Indicator Survey dataset. The data analysed were restricted to women aged 15-49 years who reported having a live birth within the two years preceding the survey. A modified Poisson regression model was used to determine factors associated with SP uptake during pregnancy. Geospatial analysis was employed to map the spatial distribution of optimal SP uptake across the ten regions of Ghana using R software. The likelihood that pregnant women received optimal SP correlated with early initiation of first antenatal care (ANC), number of ANC contacts, woman's age, region of residence, and family size. Overall, the greater the number of ANC contacts, the more likely for pregnant women to receive optimal SP. Women with four or more ANC contacts were 2 times (aPR: 2.16; 95% CI: [1.34-3.25]) more likely to receive optimal SP than pregnant women with fewer than four ANC contacts. In addition, early initiation and a high number of ANC contacts were associated with a high number of times a pregnant woman received SP. Regarding spatial distribution, a high uptake of optimal SP was significantly observed in the Upper East and Upper West Regions, whereas the lowest was observed in the Eastern Region of Ghana. In Ghana, there were regional disparities in the uptake of SP during pregnancy, with the uptake mainly correlated with the provision of ANC services. To achieve the country's target for malaria control during pregnancy, there is a need to strengthen intermittent preventive treatment for malaria during pregnancy by prioritizing comprehensive ANC services.