novel subgroup of rhadinoviruses in ruminants

In the course of investigating the malignant catarrhal fever (MCF) subgroup of rhadinoviruses, seven novel rhadinoviruses were identified in a variety of ruminants, including domestic sheep, bighorn sheep, bison, black-tailed deer, mule deer, fallow deer, elk and addax. Based on the DNA polymerase g...

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Bibliographic Details
Published inJournal of general virology Vol. 86; no. 11; pp. 3021 - 3026
Main Authors Li, H, Gailbreath, K, Flach, E.J, Taus, N.S, Cooley, J, Keller, J, Russell, G.C, Knowles, D.P, Haig, D.M, Oaks, J.L
Format Journal Article
LanguageEnglish
Published Reading Soc General Microbiol 01.11.2005
Society for General Microbiology
Subjects
Animals
Biological and medical sciences
Bovine herpesvirus 4
DNA-directed DNA polymerase
epitopes
Fundamental and applied biological sciences. Psychology
Gammaherpesvirus
genes
Microbiology
Miscellaneous
Molecular Sequence Data
nucleotide sequences
Phylogeny
Rhadinovirus
Rhadinovirus - classification
Rhadinovirus - genetics
Ruminantia
ruminants
Ruminants - virology
Sequence Alignment
Sequence Analysis, DNA
taxonomy
viral antigens
viral diseases of animals and humans
Virology
Microbiology
Virology
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Summary:In the course of investigating the malignant catarrhal fever (MCF) subgroup of rhadinoviruses, seven novel rhadinoviruses were identified in a variety of ruminants, including domestic sheep, bighorn sheep, bison, black-tailed deer, mule deer, fallow deer, elk and addax. Based on the DNA polymerase gene sequences, these newly recognized viruses clustered into a second distinct subgroup in ruminants with three members identified previously in cattle, goats and oryx. Phylogenetic analysis revealed that the currently known ruminant rhadinoviruses appear to comprise three distinct genetic lineages: (i) the MCF subgroup, defined by sequence identity and the presence of the 15A antigenic epitope; (ii) a second distinct subgroup, devoid of the 15A epitope, which contains the previously reported bovine lymphotropic herpesvirus and related viruses; and (iii) a third distinct subgroup represented by Bovine herpesvirus 4. Comparison of phylogenetic trees between the rhadinoviruses and their corresponding hosts further supports the gammaherpesvirus and host co-evolution theory.
Bibliography:http://hdl.handle.net/10113/14661
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-1317
1465-2099
DOI:10.1099/vir.0.81238-0