Impaired proprioception and magnified scaling of proprioceptive error responses in chronic stroke

• Published in: Journal of neuroengineering and rehabilitation Vol. 21; no. 1; pp. 51 - 15
• Main Authors: Tulimieri, Duncan Thibodeau, Semrau, Jennifer A
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 09.04.2024; BioMed Central; BMC
• Subjects: Analysis; Diabetic neuropathy; Distance; Errors; Humans; Information processing; Methods; Motor learning; Movement - physiology; Prevention; Proprioception; Proprioception - physiology; Risk factors; Robotics; Robotics - methods; Robots; Sensorimotor; Speed; Stroke; Stroke (Disease); Stroke - complications; Stroke Rehabilitation - methods; United States; Speed; Stroke; Proprioception; Distance; Robotics; Sensorimotor
• ISSN: 1743-0003; 1743-0003
• DOI: 10.1186/s12984-024-01350-9

Previous work has shown that ~ 50-60% of individuals have impaired proprioception after stroke. Typically, these studies have identified proprioceptive impairments using a narrow range of reference movements. While this has been important for identifying the prevalence of proprioceptive impairments, it is unknown whether these error responses are consistent for a broad range of reference movements. The objective of this study was to characterize proprioceptive accuracy as function of movement speed and distance in stroke. Stroke (N = 25) and controls (N = 21) completed a robotic proprioception test that varied movement speed and distance. Participants mirror-matched various reference movement speeds (0.1-0.4 m/s) and distances (7.5-17.5 cm). Spatial and temporal parameters known to quantify proprioception were used to determine group differences in proprioceptive accuracy, and whether patterns of proprioceptive error were consistent across testing conditions within and across groups. Overall, we found that stroke participants had impaired proprioception compared to controls. Proprioceptive errors related to tested reference movement scaled similarly to controls, but some errors showed amplified scaling (e.g., significantly overshooting or undershooting reference speed). Further, interaction effects were present for speed and distance reference combinations at the extremes of the testing distribution. We found that stroke participants have impaired proprioception and that some proprioceptive errors were dependent on characteristics of the movement (e.g., speed) and that reference movements at the extremes of the testing distribution resulted in significantly larger proprioceptive errors for the stroke group. Understanding how sensory information is utilized across a broad spectrum of movements after stroke may aid design of rehabilitation programs.