Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

• Published in: Nature (London) Vol. 349; no. 6311; pp. 669 - 676
• Main Authors: Peters, Peter J, Neefjes, Jacques J, Oorschot, Viola, Ploegh, Hidde L, Geuze, Hans J
• Format: Journal Article
• Language: English
• Published: London Nature Publishing 21.02.1991; Nature Publishing Group
• Subjects: Antigen presentation; Antigens; Antigens, CD; B-Lymphocytes - metabolism; beta-N-Acetylhexosaminidases - analysis; Biological and medical sciences; Biological Transport; Biosynthesis; Cell Line, Transformed; Cellular biology; Compartments; Endocytosis - immunology; Enzymes; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Golgi apparatus; Golgi Apparatus - metabolism; Herpesvirus 4, Human; Histocompatibility antigens (hla, h-2 and other systems); Histocompatibility Antigens Class I - metabolism; HLA-D Antigens - biosynthesis; HLA-D Antigens - metabolism; Humans; lymphoblastoid cell lines; Lymphocytes; Lymphocytes B; Lymphocytes T; Lysosomal Membrane Proteins; Lysosomes; Lysosomes - chemistry; Lysosomes - metabolism; Major histocompatibility complex; Medical research; Membrane Glycoproteins - analysis; Membrane Proteins - analysis; Molecular immunology; Molecules; Organelles - chemistry; Peptides; Platelet Membrane Glycoproteins; Receptor, IGF Type 2; Receptors, Cell Surface - analysis; Tetraspanin 30; Human; Antigen presentation; Intracellular transport; Major histocompatibility system; Class II histocompatibility antigen; Lysosome; Biosynthesis; B-Lymphocyte; Golgi apparatus; Dichotomy; Distribution; Intracellular; Lymphoblastoid cell; Class I histocompatibility antigen
• ISSN: 0028-0836; 1476-4687
• DOI: 10.1038/349669a0

Traffic of MHC molecules dictates the source of peptides that are presented to T cells. The intracellular distribution of MHC class I and class II molecules reflects the dichotomy in presentation of antigen from endogenous and exogenous origin, respectively. In human B lymphoblastoid cells, class I molecules are present in compartments constituting the biosynthetic pathway, whereas class II molecules enter structures related to lysosomes during their biosynthesis.